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  • merck millipore,默克密理博,CC1019,Human Integrin αVβ3, Triton X-100 Formulation

  • merck millipore,默克密理博,CC1019,Human Integrin αVβ3, Triton X-100 Formulation

    产品名称：Human Integrin αVβ3, Triton X-100 Formulation
    产品型号：CC1019


    merck millipore,默克密理博,CC1019,Human Integrin αVβ3, Triton X-100 Formulation

  • 产品介绍
  • merck millipore,默克密理博,CC1019,Human Integrin αVβ3, Triton X-100 Formulation

    描述
    产品目录编号 CC1019
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Human Integrin αVβ3, Triton X-100 Formulation
    概述 Integrin alphaVbeta3 was purified from human placenta by affinity chromatography using immobilized monoclonal antibodies to aVb3 integrin. A tissue detergent extract, which was applied to the column was prepared as previously described (Belkin, 1990).
    Alternate Names
    • CD51/CD61
    产品信息
    演示 Purified protein in 20 mM Tris-HCI, pH 7.5, 150 mM NaCI, 2 mM MgCI2, 0.2% Triton X-100. No preservatives.
    应用
    主要应用
    • Positive Control
    应用说明 Electrophoresis and Immunoblotting control. Also useful for in vitro binding experiments with metalloproteinase MMP-2.

    Optimal working dilutions must be determined by end user.
    生物信息
    浓缩 0.2 mg/mL
    纯度 > 95% pure by gel analysis. Nonreduced 7.5% PAAG stained with Silver stain shows major bands at 92 kDa (beta3 subunit), 145 kDa (alphaV subunit) and a minor band at 170 kDa (beta3 subunit dimer).
    品种 Human
    特异活性 Functional activity confirmed by interaction of integrin alphaV/beta3 with vitronectin, von Willebrand Factor, fibrinogen, and fibronectin in RGD-dependent ELISA testing.
    Entrez基因编号
    • NM_002210.2
    Entrez基因汇总 ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.
    基因符号
    • VNRA
    • ITGAV
    • DKFZp686A08142
    • MSK8
    • CD51
    UniProt编号
    • P06756
    UniProt汇总 FUNCTION: SwissProt: P06756 # The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
    SIZE: 1048 amino acids; 116038 Da
    SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    SIMILARITY: SwissProt: P06756 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -70°C in undiluted aliquots. Avoid repeated freeze/ thaw cycles.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,CC1019,Human Integrin αVβ3, Triton X-100 Formulation

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