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Replacement Information Replacement Information AB3239 is a recommended replacement for MAB10102. 重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H WB, ICC, IHC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB3239 Replaces MAB10102 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Myostatin Antibody, Near CT Alternate Names - growth differentiation factor 8
背景信息 Myostatin (GDF8) is expressed uniquely in human skeletal muscle as a 12 kDa mature glycoprotein consisting of 113 amino acid residues and secreted into plasma. Myostatin is a member of the transforming growth factor ß superfamily of secreted growth and differentiation factors that is essential for proper regulation of skeletal muscle mass. Studies have shown that myostatin could play an important role in cardiac development and physiology. 产品信息 格式 Affinity Purified 控制 - Skeletal muscle
演示 Affinity purified rabbit polyclonal in buffer containing Tris-citrate/phosphate, pH 7-8 containing 0.1% sodium azide 应用 应用 Anti-Myostatin Antibody, Near C-terminus is an antibody against Myostatin for use in IC, IH, IH(P) & WB. 主要应用 - Western Blotting
- Immunocytochemistry
- Immunohistochemistry
应用说明 Immunohistochemistry:
1:250-1:1,000
Western blot:
A 1:500-1:5,000 dilution of a previous lot was used in western blot. Recognizes a band migrating at approximately 26 kDa.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide corresponding to a portion of human Myostatin. Synthetic peptide corresponding to amino acids 349-364 of human Myostatin. 表位 Near C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Myostatin (Growth and Differentiation Factor 8, GDF8). Recognizes the mature forms of myostatin. 品种反应性 MouseHuman Species Reactivity Note Human and mouse. Other species have not been tested. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_005259.2
Entrez基因汇总 The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth. 基因符号 - GDF8
- MSTN
- GDF-8
纯化方法 Immunoaffinity purified UniProt编号 - O14793
UniProt汇总 FUNCTION: SwissProt: O14793 # Acts specifically as a negative regulator of skeletal muscle growth.
SIZE: 375 amino acids; 42750 Da
SUBUNIT: Homodimer; disulfide-linked (By similarity). Interacts with WFIKKN2, leading to inhibit its activity.
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: SwissProt: O14793 ## Belongs to the TGF-beta family.产品使用声明 质量保证 Evaluated by immunohistochemistry(paraffin) on mouse muscle.
Immunohistochemistry(paraffin):
Optimal Staining Without Epitope Retrieval: Mouse Muscle使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 6 months at 2-8ºC from date of receipt. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 50 µg
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