merck millipore,默克密理博,MAB1399Z,Anti-Integrin αX Antibody, clone N418, azide free

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merck millipore,默克密理博,MAB1399Z,Anti-Integrin αX Antibody, clone N418, azide free
产品名称：Anti-Integrin αX Antibody, clone N418, azide free
产品型号：MAB1399Z
Anti-Integrin αX Antibody, clone N418, azide free is an antibody against Integrin αX for use in FC, IH.

merck millipore,默克密理博,MAB1399Z,Anti-Integrin αX Antibody, clone N418, azide free

产品介绍

merck millipore,默克密理博,MAB1399Z,Anti-Integrin αX Antibody, clone N418, azide free

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
M	IHC, FC	AHm	Purified	Monoclonal Antibody

描述
产品目录编号	MAB1399Z
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-Integrin αX Antibody, clone N418, azide free
Alternate Names	MAB1399 CD11c

产品信息
格式	Purified
演示	Purified IgG affinity purified on Protein G from tissue culture supernatant. Liquid in phosphate buffered saline, pH7.4 with no preservatives.

应用
应用	Anti-Integrin αX Antibody, clone N418, azide free is an antibody against Integrin αX for use in FC, IH.
主要应用	Immunohistochemistry Flow Cytometry
应用说明	Flow cytometry - 1:25-1:100 (10μL of working dilution for 10E6 cells in 100μL) Immunohistology on frozen tissue sections Immunoprecipitation (Metaly et al., 1990) Optimal working dilutions must be determined by end user.

生物信息
克隆	N418
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Armenian Hamster
特异性	Recognizes the murine homolog of human CD11c; a 150/90kDa member of the β2 integrin family. In mice, CD11c is primarily expressed by dendritic cells. Clone N418 has been reported to enhance antigen specific responses when used to target dendritic cells in vivo (Metaly et al., 1990).
同种型	IgG
品种反应性	Mouse
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_000887.3
Entrez基因汇总	This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.
基因符号	CD11C ITGAX CD11c
UniProt编号	P20702
UniProt汇总	FUNCTION: SwissProt: P20702 # Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. SIZE: 1163 amino acids; 127829 Da SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Predominantly expressed in monocytes and granulocytes. DOMAIN: SwissProt: P20702 The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. & Contains 1 VWFA domain.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Store at -20°C in undiluted aliquots. Avoid repeated freeze-thaw cycles. Important Note: During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifugining the v ial in a tab letop centrifuge to dislodge any liquid in the container's cap.

储存和货运信息

存储条件

Store at -20°C in undiluted aliquots. Avoid repeated freeze-thaw cycles.

Important Note: During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifugining the v ial in a tab letop centrifuge to dislodge any liquid in the container's cap.