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品种反应性 主要应用 宿主 格式 抗体类型 H, M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 09-029 描述 Anti-CBX4 Antibody Alternate Names - chromobox homolog 4 (Pc class homolog, Drosophila)
- Chromobox protein homolog 4
- NS5ATP1-binding protein 16
- Polycomb 2 homolog
- chromobox homolog 4
- chromobox homolog 4 (Drosophila Pc class)
背景信息 The family of Heterochromatin Proteins ("Chromobox Homolog", CBX) are highly conserved adapter molecules, which have important functions in the cell nucleus. These functions include gene repression by heterochromatin formation, transcriptional activation, regulation of binding of cohesion complexes to centromere, sequesteration of genes to nuclear periphery, transcriptional arrest, maintenance of heterochromatin integrity, gene repression at single nucleosome level, and gene repression by heterochromatization of euchromatin. 产品信息 格式 Purified 控制 - NIH/3T3 nuclear extract, HeLa cell nuclear extract
演示 Purified rabbit polyclonal in buffer containing PBS and 0.05% sodium azide. 应用 应用 Anti-CBX4 Antibody is a Rabbit Polyclonal Antibody for detection of CBX4 also known as Chromobox protein homolog 4 & has been validated in WB. 主要应用 - Western Blotting
应用说明 SNAP I.D. (western blotting technique): A previous lot of this antibody worked successfully using the SNAP I.D. western blotting device and technique. 生物信息 免疫原品种 GST-tagged recombinant protein corresponding to the postchromo domain of CBX4. 表位 Postchromo Domain 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody detects the postchromo domain of CBX4. 品种反应性 HumanMouse Species Reactivity Note Mouse and human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_007625
基因符号 - hPc2
- NBP16
- PC2
- Pc2
- hPC2
纯化方法 Protein A purfied UniProt编号 - O00257
UniProt汇总 FUNCTIONS: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
PATHWAY: Protein modification; protein sumoylation.
SUBUNIT STRUCTURE: Interacts with histone H3-K9Me3 By similarity. Component of chromatin-associated class II PcG repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110, BMI1/PCGF4, CBX2/M33, CBX4/PC2, CBX8/PC3, PHC1, PHC2, PHC3, SCMH1, RING1 and RNF2/RING2. Interacts with SUV39H1 and HIPK2.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Ubiquitous.
PTM: Phosphorylated on Thr-495 by HIPK2 upon DNA damage; which enhances E3 SUMO-protein ligase activity and promotes sumoylation on Lys-492.
SEQUENCE SIMILARITIES: Contains 1 chromo domain.
产品使用声明 质量保证 Evaluated by western blot on HeLa nuclear extract.
Western Blot Analysis: 0.5-2 µg/mL of this antibody detected CBX4 in HeLa nuclear extract.
使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8ºC from date of receipt. 包装信息 数量 100 µg
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