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merck millipore,默克密理博,AB3212,Anti-Na+/HCO3- Cotransporter Antibody, a.a. 338-391
产品名称：Anti-Na+/HCO3- Cotransporter Antibody, a.a. 338-391
产品型号：AB3212
Detect Na+/HCO3-Cotransporter using this Anti-Na+/HCO3-Cotransporter Antibody, a.a. 338-391 validated for use in IC, IH & WB.
merck millipore,默克密理博,AB3212,Anti-Na+/HCO3- Cotransporter Antibody, a.a. 338-391
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Sal, H, R, Rb WB, ICC, IHC Rb Serum Polyclonal Antibody 描述 产品目录编号 AB3212 Replaces AB3208 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Na+/HCO3- Cotransporter Antibody, a.a. 338-391 Alternate Names - NBC
产品信息 格式 Serum 演示 Rabbit serum. Liquid with 0.03% sodium azide. 应用 应用 Detect Na+/HCO3-Cotransporter using this Anti-Na+/HCO3-Cotransporter Antibody, a.a. 338-391 validated for use in IC, IH & WB. 主要应用 - Western Blotting
- Immunocytochemistry
- Immunohistochemistry
应用说明 Immunohistochemistry: 1:100 on PLP fixed tissues sections.
Immunocytochemistry: 1:100 on HEK-293 cells.
Western blot: 1:500-1:1,000.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Fusion protein of MBP with a.a. 338-391 of rat kidney Na+/HCO3 Cotransporter (rkNBC; Romero et al., Nature 387:409-413, 1997). This antigenic sequence is present completely (or in major parts) in most species/isoforms of NBC that have been clone 表位 a.a. 338-391 宿主 Rabbit 特异性 Recognizes the Na+/HCO3 Cotransporter (NBC) within the N-terminus a.a. 338-391. Reacts with kidney, brain, pancreas, stomach and intestine. In Western blot the antibody recognizes a major band of approximately 130 kDa in rat and rabbit and a major band of approximately 160 kDa in salamander kidney. 品种反应性 SalamanderHumanRatRabbit 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_003759.2
- NM_001098484.1
Entrez基因汇总 Sodium bicarbonate cotransporters (NBCs) mediate the coupled movement of sodium and bicarbonate ions across the plasma membrane of many cells. This is an electrogenic process with an apparent stoichiometry of 3 bicarbonate ions per sodium ion. Sodium bicarbonate cotransport is involved in bicarbonate secretion/absorption and intracellular pH regulation. Romero and Boron (1999) [PubMed 10099707] reviewed NBCs. Soleimani and Burnham (2000) [PubMed 10652014] reviewed NBCs and their regulation in physiologic and pathophysiologic states.[supplied by OMIM] 基因符号 - HHNMC
- hhNMC
- kNBC1
- HNBC1
- SLC4A5
- Na
- DKFZp781H1314
- SLC4A4
- +HCO3
- KNBC
- NBCE1
- pNBC
- NBC
- -cotransporter)
- NBC2
- NBC1
UniProt编号 - Q9Y6R1
UniProt汇总 FUNCTION: SwissProt: Q9Y6R1 # Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.
SIZE: 1079 amino acids; 121461 Da
SUBUNIT: Interacts with CA2/carbonic anhydrase 2 and CA4/carbonic anhydrase 4 which may regulate transporter activity.
SUBCELLULAR LOCATION: Basolateral cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Isoform 1 is expressed in pancreas and to a lower extent in heart, skeletal muscle, liver, parotid salivary glands, prostate, colon, stomach, thyroid, brain and spinal chord. Corneal endothelium cells express only isoform 1 (at protein level). Isoform 2 is specifically expressed in kidney at the level of proximal tubules.
PTM: Phosphorylation of Ser-1026 by PKA increases the binding of CA2 and changes the Na(+):HCO3(-) stoichiometry of the transporter from 3:1 to 2:1. Phosphorylation of Thr-49 regulates isoform 1 conductance. & N-glycosylation is not necessary for the transporter basic functions.
DISEASE: "SwissProt: Q9Y6R1 # Defects in SLC4A4 are the cause of proximal renal tubular acidosis with ocular abnormalities [MIM:604278]; also known as renal tubular acidosis II. Caused by an impairment of bicarbonate absorption in the proximal tubule, proximal renal tubular acidosis (pRTA) is characterized by a decreased renal HCO3(-) threshold. PRTA with ocular abnormalities is an extremely rare autosomal recessive syndrome characterized by short stature, profound pRTA, mental retardation, bilateral glaucoma, cataracts and bandkeratopathy."
SIMILARITY: SwissProt: Q9Y6R1 ## Belongs to the anion exchanger (TC 2.A.31) family.
MISCELLANEOUS: Loss of interaction and stimulation by CA4 is the cause of retinitis pigmentosa 19 (RP19).产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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