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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-1381 描述 Anti-PP6R3 Antibody Alternate Names - Sporulation-induced transcript 4-associated protein SAPL
- Serine/threonine-protein phosphatase 6 regulatory subunit 3
- SAPS domain family member 3
背景信息 PP6R3 (protein Ser/Thr phosphatase 6 regulatory subunit 3), also known as SAPS3 is a regulatory subunit of protein phosphatase 6 which is important for cell survival and is associated with TOR signaling in yeast. PP6R3 has been implicated in the transition from G1 to the S phase of mitosis. The PP6R3 subunit is one of three human versions of SAPs which may also have a role to play in regulation of NF-kappaB. 产品信息 格式 Affinity Purified 控制 - HeLa cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-PP6R3 Antibody detects level of PP6R3 & has been published & validated for use in WB, IH(P). 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: 1:200 dilution of a representative lot detected PP6R3 in human kidney and human breast tissues. 生物信息 免疫原品种 Histidine-tagged-recombinant protein corresponding to human PP6R3. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001157634
Entrez基因汇总 Summary: Protein phosphatase regulatory subunits, such as SAPS3, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS3 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM]. 基因符号 - SAPS3
- PPP6R3
- C11orf23
- KIAA1558
- PP6R3
- SAPL
纯化方法 Affinity purified UniProt编号 - Q5H9R7
UniProt汇总 FUNCTION: Regulatory subunit of protein phospatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance.
SUBUNIT STRUCTURE: Protein phospatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6C and ANKRD28.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
TISSUE SPECIFICITY: Expressed in skeletal muscle, placenta, heart, pancreas, testis, brain, lung, liver, kidney, spleen, thymus, prostate, small intestine, colon and leukocytes.
POST-TRANSLATIONAL MODIFICATION: Phosphorylated upon DNA damage, probably by ATM or ATR.
SEQUENCE SIMILARITIES: Belongs to the SAPS family.
SEQUENCE CAUTION: The sequence AAZ99639.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAA91978.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB13384.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAB71396.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.产品使用声明 质量保证 Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: 1:10,000 dilution of this antibody detected PP6R3 on 10 µg of HeLa cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
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