merck millipore,默克密理博,AB3083,Anti-Na+/H+ Exchanger-2 Antibody

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merck millipore,默克密理博,AB3083,Anti-Na+/H+ Exchanger-2 Antibody
产品名称：Anti-Na+/H+ Exchanger-2 Antibody
产品型号：AB3083
Anti-Na+/H+ Exchanger-2 Antibody is an antibody against Na+/H+ Exchanger-2 for use in ELISA & WB.

merck millipore,默克密理博,AB3083,Anti-Na+/H+ Exchanger-2 Antibody

产品介绍

merck millipore,默克密理博,AB3083,Anti-Na+/H+ Exchanger-2 Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R	WB, ELISA	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	AB3083
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-Na+/H+ Exchanger-2 Antibody
Alternate Names	NHE2
背景信息	Na+/H+ exchangers (NHE) of mammalian cells are plasma membrane intrinsic proteins mediating exchange of Na+ and H+ ions in various tissues. The NHE catalyzes the electoneuronal transport of extracellular Na+ for intracellular H+. They play a major role in regulation of intracellular pH (pHi) addition to trans-cellular absorption of Na+, cell volume regulation and possibly in cell proliferation. These primary functions of the Na+/H+ exchanger have been related to many pathophysiological states, include hypertension, organ growth and hypertrophy, regression of cancer and renal intestinal disorders. Five isoforms (NHE1-5) have been cloned so far. They are all similar in their primary structure and predicted to have 10-12 transmembrane domains. The COOH-terminals of NHE1, NHE2 and NHE3 are intracellular. NHE2 has been implicated in volume regulation in renal inner medullary collecting duct cells. Its mRNA is found in kidney medulla, cortex, colon, jejunum, ileum, human jejunum, ileum, duodenum, stomach and adrenal glands (Collins et al. 1990; Wang et al. 1993; Ghishan et al. 1995; Chris Yun et al. 1995; Josette & Pouyssegur 1995).

产品信息
格式	Affinity Purified
演示	Liquid in PBS with 0.1% BSA

应用
应用	Anti-Na+/H+ Exchanger-2 Antibody is an antibody against Na+/H+ Exchanger-2 for use in ELISA & WB.
主要应用	Western Blotting ELISA
应用说明	Western blot: 1-10 μg/mL using Chemiluminescence technique. The molecular weight of NHE2 is approximately 90kDa (Brookstein et al., 1994). ELISA: 1:100,000 using 50-100ng control peptide (AG784)/well. Optimal working dilutions must be determined by end user.

生物信息
免疫原品种	A 20 AA peptide within the cytoplasmic, C-terminal domain of the rat NHE2 (Collins et al. 1990; Wang et al. 1993; Ghishan et al. 1995; Chris Yun et al. 1995; Josette & Pouyssegur 1995).
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
特异性	C-terminal domain of the rat NHE2. The antibody is expected to work on human and mouse (20/20) and possibly rabbit (17/20) due to sequence conservation.
品种反应性	Rat
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_003048.3
基因符号	NHE2 SLC9A2 Na +H NHE-2
UniProt编号	Q9UBY0
UniProt汇总	FUNCTION: SwissProt: Q9UBY0 # Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption. SIZE: 812 amino acids; 91520 Da SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in skeletal muscle, colon and kidney. Lower levels in the testis, prostate, ovary, and small intestine. PTM: Phosphorylated (Possible). SIMILARITY: SwissProt: Q9UBY0 ## Belongs to the Na(+)/H(+) exchanger (TC 2.A.36.5.1) family.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain frozen at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.

储存和货运信息

存储条件

Maintain frozen at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.