merck millipore,默克密理愽
  • merck millipore,默克密理博,567733,S1P₁ Receptor Agonist, SEW2871 - CAS 256414-75-2 - Calbiochem

  • merck millipore,默克密理博,567733,S1P₁ Receptor Agonist, SEW2871 - CAS 256414-75-2 - Calbiochem

    产品名称：S1P₁ Receptor Agonist, SEW2871 - CAS 256414-75-2 - Calbiochem
    产品型号：567733
    The S1P1 Receptor Agonist, SEW2871, also referenced under CAS 256414-75-2, controls the biological activity of S1P1 Receptor. This small molecule/inhibitor is primarily used for Activators More>>

    merck millipore,默克密理博,567733,S1P₁ Receptor Agonist, SEW2871 - CAS 256414-75-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,567733,S1P₁ Receptor Agonist, SEW2871 - CAS 256414-75-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₀H₁₀F₆N₂OS256414-75-2
    描述
    概述 A cell-permeable oxadiazolothienyl compound that acts as a potent and highly selective S1P1 agonist (EC50 = 13 nM and 20.7 nM in GTPS1Pγ binding assay using human and murine S1P1, respectively). Shown to induce S1P1-mediated cellular functions in vitro and peripheral blood lymphopenia (oral ED50 = 5.5 mg/kg) in mice in vivo. Unlike sphingosine-1-phosphate (Cat. No. 567727) and other known S1P receptor agonists, SEW2871 exhibits no activity towards other S1P receptor subtypes, S1P2-5, even at concentrations as high as 10 µM.
    产品目录编号 567733
    品牌系列 Calbiochem®
    同义词 Sphingosine-1-Phosphate₁ Receptor S1P1 Agonist, 5-(4-Phenyl-5-trifluoromethylthiophen-2-yl)-3-(3-trifluoromethylphenyl)-(1,2,4)-oxadiazole, SEW2871
    参考
    参考 Sanna, M.G., et al. 2004. J. Biol. Chem. 279, 13839.
    产品信息
    CAS号 256414-75-2
    具有ATP竞争性 N
    形式 White solid
    Hill配方 C₂₀H₁₀F₆N₂OS
    化学配方 C₂₀H₁₀F₆N₂OS
    Molar Mass 440.4
    可逆 N
    结构配方图像
    生物信息
    主靶 S1P1 Receptor
    主靶IC50 EC50 = 13 nM and 20.7 nM in GTPS1Pγ binding assay using human and murine S1P1, respectively
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,567733,S1P₁ Receptor Agonist, SEW2871 - CAS 256414-75-2 - Calbiochem

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