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merck millipore,默克密理博,MABN688,Anti-PTH1R Antibody, clone 4D2
产品名称：Anti-PTH1R Antibody, clone 4D2
产品型号：MABN688
Anti-PTH1R Antibody, clone 4D2 is a highly specific mouse monoclonal antibody, that targets PTHR1 & has been tested in western blotting, IHC & Immunofluorescence.
merck millipore,默克密理博,MABN688,Anti-PTH1R Antibody, clone 4D2
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB M Ascites Monoclonal Antibody 描述 产品目录编号 MABN688 描述 Anti-PTH1R Antibody, clone 4D2 Alternate Names - PTH1R
- Parathyroid hormone 2 receptor
- PTH2 receptor
背景信息 Parathyroid hormone-related peptide receptor (PTH1R) or alternatively known as PTH/PTHr receptor is encoded by the human gene named PTH1R/PTHR/PTHR1. The protein is the receptor for parathyroid hormone and for parathyroid hormone related peptide. It is a multi-pass G-protein coupled receptor localized to the cell membrane. It is expressed in most tissues but particularly in the kidney, bone and liver. The activity of the receptor is mediated through adenyl cyclase, phospholipase C, and phosphatidylinositol-calcium secondary messenger pathways. Parathyroid hormone related peptide regulates calcium ion homeostasis and when PTH1R is activated by ligand binding osteoblasts express RANKL which binds RANK on osteoclasts, which activates them to increase the resorption of calcium. Defects in PTH1R cause various defects in cartilage, bone, and tooth development as well as tumors of bone and cartilage. EMD-Millipore’s Anti-PTH1R mouse monoclonal antibody has been tested in western blot on transfected recombinant protein and in paraffin embedded immunohistochemistry on human kidney tissue sections and fluorescent immunocytochemistry on SK-BR-3 cells in culture. 产品信息 格式 Ascites 控制 - PTH1R-hIgGFc transfected HEK293 cell lysate
演示 Mouse monoclonal IgG1 ascitic fluid containing up to 0.1% sodium azide. 应用 应用 Anti-PTH1R Antibody, clone 4D2 is a highly specific mouse monoclonal antibody, that targets PTHR1 & has been tested in western blotting, IHC & Immunofluorescence. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:200-1,000 dilution from a representative lot detected PTH1R in human kidney tissue.
Immunofluorescence Analysis: A 1:200-1,000 dilution from a representative lot detected PTH1R in SK-BR-3 cells.
Optimal working dilutions must be determined by end user.
生物信息 免疫原品种 Purified recombinant fragment of human PTH1R expressed in E. Coli. 克隆 4D2 宿主 Mouse 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody 基因符号 - PTH1R
- PFE
- PTHR
- PTHR1
- MGC138426
- MGC138452
纯化方法 Unpurified UniProt编号 - P49190
产品使用声明 质量保证 Evaluated by Western Blotting in PTH1R-hIgGFc transfected HEK293 cell lysate.
Western Blotting Analysis: A 1:500-2,000 dilution of this antibody detected PTH1R-hIgGFc transfected HEK293 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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