merck millipore,默克密理愽
  • merck millipore,默克密理博,14-423,PKR agarose Protein, active, 12 µg

  • merck millipore,默克密理博,14-423,PKR agarose Protein, active, 12 µg

    产品名称：PKR agarose Protein, active, 12 µg
    产品型号：14-423
    Active, full-length human PKR, containing a GST tag, for use in Kinase Assays.

    merck millipore,默克密理博,14-423,PKR agarose Protein, active, 12 µg

  • 产品介绍
  • merck millipore,默克密理博,14-423,PKR agarose Protein, active, 12 µg

    描述
    产品目录编号 14-423
    品牌系列 Upstate
    商名
    • Upstate
    描述 PKR agarose Protein, active, 12 µg
    概述 Full-length human PKR, containing a GST tag
    应用
    应用 Active, full-length human PKR, containing a GST tag, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 expressed in E. coli
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_002759.1
    基因符号
    • PKR
    • EIF2AK2
    • MGC126524
    • EIF2AK1
    • PRKR
    蛋白靶 PKR
    靶子系列 Misc
    UniProt编号
    • P19525
    UniProt汇总 FUNCTION: SwissProt: P19525 # Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.
    SIZE: 551 amino acids; 62094 Da
    SUBUNIT: Homodimer. Interacts with STRBP (By similarity). Interacts with DNAJC3. Inhibited by direct interaction with viral proteins such as HCV E2, HCV NS5A and influenza A NS1. Activated by the interaction with HIV-1 Tat.
    PTM: Autophosphorylated on several Ser and Thr residues. Autophosphorylation of Thr-451 is dependent on Thr-446 and is stimulated by dsRNA binding and dimerization. Autophosphorylation apparently leads to the activation of the kinase.
    SIMILARITY: SwissProt: P19525 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. & Contains 2 DRBM (double-stranded RNA-binding) domains. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by autophosphorylation in vitro
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -20 C
    包装信息
    数量 12 µg

    merck millipore,默克密理博,14-423,PKR agarose Protein, active, 12 µg

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