merck millipore,默克密理博,MABN1091,Anti-Tug Antibody, clone EPR8615, rabbit monoclonal

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merck millipore,默克密理博,MABN1091,Anti-Tug Antibody, clone EPR8615, rabbit monoclonal
产品名称：Anti-Tug Antibody, clone EPR8615, rabbit monoclonal
产品型号：MABN1091
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect Tug using this rabbit monoclonal antibody, An More>>

merck millipore,默克密理博,MABN1091,Anti-Tug Antibody, clone EPR8615, rabbit monoclonal

产品介绍

merck millipore,默克密理博,MABN1091,Anti-Tug Antibody, clone EPR8615, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	IHC, WB	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	MABN1091
描述	Anti-Tug Antibody, clone EPR8615, rabbit monoclonal
Alternate Names	UBX domain-containing protein 9 Tether containing UBX domain for GLUT4 Alveolar soft part sarcoma chromosomal region candidate gene 1 protein Alveolar soft part sarcoma locus Renal papillary cell carcinoma protein 17
背景信息	In eukaryotic cells, protein secretion and the transport of materials between membrane-bounded organelles requires efficient and accurate delivery of carrier vesicles to their correct destination. Tug is a tethering protein. That means it secures its target protein in one location away from a membrane and then facilitates its release and redistribution in the membrane under another set of conditions. Tug is the short name for Tether containing UBX domain for GLUT4, TUG-UBL1, or also called in earlier literature, Alveolar soft part sarcoma chromosomal region candidate gene 1 protein, Alveolar soft part sarcoma locus, Renal papillary cell carcinoma protein 17 and UBX domain-containing protein 9. Tug is encoded by the ASPSCR1 gene, also known as ASPL, RCC17, TUG, UBXD9, and UBXN9. Tug’s target is the glucose transporter GLUT4 and essential transporter in muscle and brain. Tug controls GLUT4’s position from intracellular surface and its release to the outer cellular surface. Tug binds directly and specifically to GLUT4 and retains it inside cells in the absence of insulin. In the presence of insulin, Tug dissociates from GLUT4 allowing GLUT4 and the vesicles containing it to move to outer surface and fulfill its transport function of bringing glucose into cells. Disruption of Tug expression or action either via knockdown or competition disrupts the normal GLUT4 disposition even in the absence of insulin and interestingly when function is disrupted GLUT4 degradation is accelerated via lysosomoal shuttling. EMD-Millipore’s Anti-Tug rabbit monoclonal antibody has been tested in western blot on human K562, 293T and SW480 cell lysates and in immunohistochemistry on paraffin embedded human colon tissue.

产品信息
格式	Unpurified
控制	MCF-7, THP-1, HeLa, and HepG2 cell lysates
演示	Rabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect Tug using this rabbit monoclonal antibody, Anti-Tug Antibody, clone EPR8615 validated for use in western blotting & IHC.
主要应用	Immunohistochemistry Western Blotting
应用说明	Immunohistochemistry Analysis: A 1:100-250 dilution from a representative lot detected Tug in human colon tissue. Optimal working dilutions must be determined by end user.

生物信息
免疫原品种	Synthetic peptide corresponding to human Tug.
克隆	EPR8615
宿主	Rabbit
品种反应性	Human
抗体类型	Monoclonal Antibody
基因符号	Tug ASPL RCC17 TUG UBXD9 UBXN9 ASPSCR1
纯化方法	Unpurified
UniProt编号	Q9BZE9

产品使用声明
质量保证	Evaluated by Western Blotting in MCF-7, THP-1, HeLa, and HepG2 cell lysates. Western Blotting Analysis: A 1:10,000-50,000 dilution of this antibody detected MCF-7, THP-1, HeLa, and HepG2 cell lysates.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.