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品种反应性 主要应用 宿主 格式 抗体类型 H, B, R WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB2299 描述 Anti-NR2E3 Antibody Alternate Names - photoreceptor-specific nuclear receptor
- Nuclear receptor subfamily 2 group E member 3
- Retina-specific nuclear receptor
- nuclear receptor subfamily 2, group E, member 3
- group E
- member 3
背景信息 NR2E3 protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. 产品信息 格式 Purified 控制 - Bovine Retina tissue lysate.
演示 Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3. 应用 应用 Anti-NR2E3 Antibody is an antibody against NR2E3 for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Full Length Recombinant Protein. 表位 Full Length Protein 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Cat. # AB2299 recognizes NR2E3 protein. 品种反应性 HumanBovineRat Species Reactivity Note Bovine (Calf). May react with mouse, rat and human based on sequence homology. Reactivity with other species has not been determined. 抗体类型 Polyclonal Antibody 基因符号 - rd7
- ESCS
- MGC49976
- PNR
- RNR
- RP37
纯化方法 Purified by GST-depletion followed by Protein A UniProt编号 - Q9Y5X4
UniProt汇总 FUNCTION: Transcription factor that may have a role in the regulation of signaling pathways intrinsic to the photoreceptor cell function.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Eye specific; found solely in the outer nuclear layer of the adult neurosensory retina, where the nuclei of cone and rod photoreceptors reside.
DISEASE: Defects in NR2E3 are a cause of enhanced S cone syndrome (ESCS) [MIM:268100]. ESCS is an autosomal recessive retinopathy in which patients have increased sensitivity to blue light; perception of blue light is mediated by what is normally the least populous cone photoreceptor subtype, the S (short wavelength, blue) cones. ESCS is also associated with visual loss, with night blindness occurring from early in life, varying degrees of L (long, red)- and M (middle, green)-cone vision, and retinal degeneration. Ref.5 Ref.6 Ref.7 Ref.8
Defects in NR2E3 are the cause of retinitis pigmentosa type 37 (RP37) [MIM:611131]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP37 inheritance is autosomal dominant. Ref.9
SEQUENCE SIMILARITY: Belongs to the nuclear hormone receptor family. NR2 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
产品使用声明 质量保证 Western Blot: 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8ºC from date of receipt. 包装信息 数量 200 µg
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