merck millipore,默克密理博,05-717,Anti-Adenosine Receptor A2a Antibody, clone 7F6-G5-A2

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
Ca, H, R, M, Rb	WB, FC, IHC	M	Purified	Monoclonal Antibody

描述
产品目录编号	05-717
品牌系列	Upstate
商名	Upstate
描述	Anti-Adenosine Receptor A2a Antibody, clone 7F6-G5-A2
Alternate Names	adenosine receptor subtype A2a adenosine A2a receptor adenosine A2 receptor
背景信息	Adenosine receptors, a class of purinergic G-protein coupled receptors with adenosine as endogenous ligands mediate several receptor subtype-specific physiological processes that include cardiac rate, smooth muscle tone, platelet aggregation, inflammation, cell growth and death, and neurotransmission. The activity of A2A adenosine receptor is mediated by G proteins which activate adenylyl cyclase. It is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine. Adenosine receptor A2A-R contributes to motoneuron survival by transactivating the tyrosine kinase receptor TrkB and may suggest a new strategy for using this mechanism in neurodegenerative diseases.

产品信息
格式	Purified
控制	Brain tissue
演示	Purified mouse monoclonal IgG2ak in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide

应用
应用	Anti-Adenosine Receptor A2a Antibody, clone 7F6-G5-A2 is an antibody against Adenosine Receptor A2a clone 7F6-G5-A2 for use in FC, IH & WB.
主要应用	Western Blotting Flow Cytometry Immunohistochemistry
应用说明	Immunohistochemistry: 1 μg/mL of a previous lot detected Adenosine Receptor A2A in paraformaldehyde-fixed mouse brain striatal sections. Not detected in Adenosine Receptor A2A knockout mice. FACS Analysis: A previous lot of this antibody has been reported by an independent laboratory to detect Adenosine Receptor A2A in transfected HEK293 cells (Koshiba, M., 1999).

生物信息
免疫原品种	6His-tagged full-length human recombinant A2A receptor. Epitope mapped to SQPLPGER in the third intracellular loop. Clone 7F6-G5-A2.
克隆	7F6-G5-A2
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
特异性	This antibody recognizes adenosine receptor A2A, Mr 43 kDa.
同种型	IgG2a
品种反应性	CanineHumanRatMouseRabbit
Species Reactivity Note	Human, mouse, rat, rabbit, and dog. Cross-reactivity with guinea pig also reported.
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_000675
Entrez基因汇总	This gene encodes a protein which is one of several receptor subtypes for adenosine. The activity of the encoded protein, a G-protein coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase. The encoded protein is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine.
基因符号	hA2aR ADORA2A ADORA2 RDC8
纯化方法	Protein G purfied
UniProt编号	P29274
UniProt汇总	FUNCTION: SwissProt: P29274 # Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. SIZE: 412 amino acids; 44707 Da SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: SwissProt: P29274 ## Belongs to the G-protein coupled receptor 1 family.

产品使用声明
质量保证	Routinely evaluated by immunohistochemistry. Western Blot Analysis: A 1:1000–1:5000 dilution of this lot of antibody detected Adenosine Receptor A2A in HEK293 cells expressing canine A1/A2A receptor chimeras (Rosin, D.L., 1998).
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt

包装信息
数量	200 µg

merck millipore,默克密理博,05-717,Anti-Adenosine Receptor A2a Antibody, clone 7F6-G5-A2

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