merck millipore,默克密理博,420200,JC-1 - CAS 47729-63-5

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merck millipore,默克密理博,420200,JC-1 - CAS 47729-63-5 - Calbiochem
产品名称：JC-1 - CAS 47729-63-5 - Calbiochem
产品型号：420200
A cationic, fluorescent, carbocyanine dye that can be used as a ratiometric indicator of mitochondrial potential δΨm in cells, tissues, and isolated mitochondria.

merck millipore,默克密理博,420200,JC-1 - CAS 47729-63-5 - Calbiochem

产品介绍

merck millipore,默克密理博,420200,JC-1 - CAS 47729-63-5 - Calbiochem

重要规格表

经验配方	CAS号
C₂₅H₂₇Cl₄IN₄	47729-63-5

描述
概述	A cationic, fluorescent, carbocyanine dye that can be used as a ratiometric indicator of mitochondrial potential ΔΨ_m in cells, tissues, and isolated mitochondria. Mitochondrial depolarization is indicated by a decrease in the red/green fluorescence intensity ratio. The potential-sensitive color shift is due to concentration-dependent formation of red fluorescent J-aggregates. Ideal for detection of collapse of ΔΨ_m induced by uncouplers of mitochondrial respiration. JC-1 has also been used in a functional assay of multidrug-resistance cells and in apoptosis-related mitochondrial modifications.
产品目录编号	420200
品牌系列	Calbiochem®
同义词	5,5ʹ,6,6ʹ-Tetrachloro-1,1ʹ,3,3ʹ-tetraethylbenzimidazolylcarbocyanine Iodide

参考
参考	Mathur, A., et al. 2000. Cardiovasc. Res. 46, 126. Gravance, C.G., et al. 2000. Theriogenology 53, 1691. Chanda, B., and Mathew, M.K. 1999. Biochim Biophys. Acta 1416, 92. Dedov, V.N., and Roufogalis, B.D. 1999. FEBS Lett. 456, 171. Polla, B.S., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6458. White, R.J., and Reynolds, I.J. 1996. J. Neurosci. 16, 5688. Ankacrona, M., et al. 1995. Neuron 15, 961. Reers, M., et al. 1995. Methods Enzymol. 260, 406. Cossarizza, A., et al. 1993. Biochem. Biophys. Res. Commun. 197, 40.

参考

Mathur, A., et al. 2000. Cardiovasc. Res. 46, 126.
Gravance, C.G., et al. 2000. Theriogenology 53, 1691.
Chanda, B., and Mathew, M.K. 1999. Biochim Biophys. Acta 1416, 92.
Dedov, V.N., and Roufogalis, B.D. 1999. FEBS Lett. 456, 171.
Polla, B.S., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6458.
White, R.J., and Reynolds, I.J. 1996. J. Neurosci. 16, 5688.
Ankacrona, M., et al. 1995. Neuron 15, 961.
Reers, M., et al. 1995. Methods Enzymol. 260, 406.
Cossarizza, A., et al. 1993. Biochem. Biophys. Res. Commun. 197, 40.

产品信息
CAS号	47729-63-5
具有ATP竞争性	N
形式	Red-orange solid
Hill配方	C₂₅H₂₇Cl₄IN₄
化学配方	C₂₅H₂₇Cl₄IN₄
Molar Mass	652.2
可逆	N
结构配方图像

生物信息
主靶	Used as a ratiometric indicator of mitochondrial potential δΨm in cells, tissues, and isolated mitochondria
纯度	≥95% by HPLC

理化信息
细胞可渗透	N
溶解度	DMF or DMSO

安全信息
R相	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S相	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Irritant
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Do not reuse thawed samples.