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品种反应性 主要应用 宿主 格式 抗体类型 M, H, R IHC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB2291 描述 Anti-Choline acetylase Antibody Alternate Names - Choline acetylase
- choline acetyltransferase
- acetyl CoA:choline O-acetyltransferase
背景信息 Acetylcholine (ACh) is a common neurotransmitter for motoneurons, preganglionic autonomic neurons, postganglionic parasympathetic neurons, a variety of brain regions and some emerging neuron-like stem cells. The metabolism of Ach is relatively simple, involving only two enzymes: choline acetylase, aka choline acetyltransferase (ChAT) for synthesis and acetylcholinesterase (AChE) for degradation. Further, acetylcholine has little function in neurons other than neurotransmission and seems to be neuron specific. It seems that only cholinergic neurons have significant amounts of ChAT making anti-cholinacetyltransferase a useful specific marker. 产品信息 格式 Affinity Purified 控制 - Human fetal brain tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 Anti-Choline acetylase Antibody is an antibody against Choline acetylase for use in WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:200 dilution of Anti-Choline acetylase antibody from a previous lot detected Choline acetylase in human cortex tissue. 生物信息 免疫原品种 GST-tagged recombinant protein corresponding to the C-terminus of human Choline acetylase. 表位 C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes Choline acetylase at the C-terminus. 品种反应性 MouseHumanRat Species Reactivity Note Demonstrated to react with human, rat, and mouse. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_066264
Entrez基因汇总 This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer disease. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq]. 基因符号 - CMS1A
- CHAT
- ChAT
- CMS1A2
- CHOACTase
纯化方法 Affinity Purfied UniProt编号 - P28329
UniProt汇总 FUNCTION: Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
SIZE: 748 amino acids; 82568 Da
DISEASE: Defects in CHAT are the cause of familial infantile myasthenia gravis 2 (FIMG2) [MIM:254210, 254200]; also known as CMS-EA. FIMG2 patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement. Inheritance is autosomal recessive.
SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.产品使用声明 质量保证 Evaluated by Western Blot in human fetal brain tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Choline acetylase in 10 µg of human fetal brain tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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