merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB4344,Anti-GATA-4 Antibody, clone 13G4.2

  • merck millipore,默克密理博,MAB4344,Anti-GATA-4 Antibody, clone 13G4.2

    产品名称：Anti-GATA-4 Antibody, clone 13G4.2
    产品型号：MAB4344
    Anti-GATA-4 Antibody, clone 13G4.2 detects level of GATA-4 & has been published & validated for use in WB, IH.

    merck millipore,默克密理博,MAB4344,Anti-GATA-4 Antibody, clone 13G4.2

  • 产品介绍
  • merck millipore,默克密理博,MAB4344,Anti-GATA-4 Antibody, clone 13G4.2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    H, MIHC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB4344
    Replaces MABE477
    描述 Anti-GATA-4 Antibody, clone 13G4.2
    Alternate Names
    • transcription factor GATA-4
    • GATA binding protein 4
    • GATA-binding protein 4
    • GATA-binding factor 4
    背景信息 GATA4 (GATA binding factor-4) is a member of the GATA family of transcription factors and is located primarily in the nucleus. GATA4 is a transcriptional activator of ANF and also acts in conjuction with NKX2-5, ZNF260, NFATC4 and LMCD1. GATA4's activation of ANF can be repressed through JARID2 interaction. GATA4 is involved in embryogenesis and in myocardial differentiation and function and is associated with heart septal defects.
    产品信息
    格式 Purified
    控制
    • Mouse heart tissue lysate
    演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-GATA-4 Antibody, clone 13G4.2 detects level of GATA-4 & has been published & validated for use in WB, IH.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: A 1:500 dilution from a previous lot detected GATA-4 in anal carcinoma/diffusive squamous cell carcinoma and prostate carcinoma tissues.
    生物信息
    免疫原品种 GST-tagged recombinant protein corresponding to human GATA-4.
    克隆 13G4.2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG2aκ
    品种反应性 HumanMouse
    Species Reactivity Note Demonstrated to react with human and mouse.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_002043
    基因符号
    • GATA-4
    • GATA4
    纯化方法 Protein G Purified
    UniProt编号
    • P43694
    UniProt汇总 FUNCTION: Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity).

    SUBUNIT STRUCTURE: Interacts with ZNF260 (By similarity). Interacts with the homeobox domain of NKX2-5 through its C-terminal zinc finger. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with NFATC4 and LMCD1 (By similarity).

    SUBCELLULAR LOCATION: Nucleus.

    INVOLVEMENT IN DISEASE: Defects in GATA4 are the cause of atrial septal defect type 2 (ASD2) [MIM:607941]. ASD2 is a congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. ASD2 patients show other heart abnormalities including ventricular and atrioventricular septal defects, pulmonary valve thickening or insufficiency of the cardiac valves. ASD2 is not associated with defects in the cardiac conduction system or non-cardiac abnormalities.

    SEQUENCE SIMILARITIES: Contains 2 GATA-type zinc fingers.
    产品使用声明
    质量保证 Evaluated by Western Blot in mouse heart tissue lysate.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected GATA-4 in 10 µg of mouse heart tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB4344,Anti-GATA-4 Antibody, clone 13G4.2

上一件merck millipore产品：merck millipore,默克密理博,MABE351,Anti-acetyl-Histone H3 (Lys14) Antibody, clone 13HH3-1A5
下一件merck millipore产品：merck millipore,默克密理博,S7710,TRAPEZE RT Telomerase Detection Kit


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