merck millipore,默克密理愽

  • 产品介绍

  • 重要规格表

    主要应用 品种 来源
    CULTHumanRecombinant human TGF-Beta 1 expressed in insect cells.
    描述
    产品目录编号 01-209
    品牌系列 Upstate
    商名
    • Upstate
    描述 TGFβ1
    产品信息
    演示 Lypholized from sodium citrate, pH 3.5
    应用
    主要应用
    • Cell Culture
    应用说明 ATP endpoint assay for cell number
    生物信息
    来源 Recombinant human TGF-Beta 1 expressed in insect cells.
    品种 Human
    Entrez基因编号
    • NM_000660.3
    Entrez基因汇总 TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA (MIM 190170) in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for this peptide. TGFB1, TGFB2 (MIM 190220), and TGFB3 (MIM 190230) all function through the same receptor signaling systems.[supplied by OMIM]
    基因符号
    • TGFB1
    • TGFB
    • DPD1
    • CED
    • TGF-beta-1
    物理形式 Lyophilized
    纯化方法 Sterilized through a 0.2 micron membrane filter
    UniProt编号
    • P01137
    UniProt汇总 FUNCTION: SwissProt: P01137 # Multifunctional protein that control proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGFB1 and essentially all of them have specific receptors for this protein. It regulates the actions of many other growth factors and determines a positive or negative direction of their effects. It plays an important role in bone remodeling. It is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.
    SIZE: 390 amino acids; 44341 Da
    SUBUNIT: The inactive form consists of a TGFB1 homodimer non- covalently linked to a latency-associated peptide (LAP) homodimer. The inactive complex can contain a latent TGFB1-binding protein. The active form is a homodimer of mature TGFB1; disulfide-linked. Heterodimers of TGFB1/TGFB2 have been found in bone. Interacts with CD109 and DPT.
    SUBCELLULAR LOCATION: Secreted.
    TISSUE SPECIFICITY: Highly expressed in bone.
    PTM: Glycosylated. & The precursor is cleaved into mature TGF-beta-1 and LAP, which remains non-covalently linked to mature TGF-beta-1 rendering it inactive.
    DISEASE: SwissProt: P01137 # Defects in TGFB1 are the cause of Camurati-Engelmann disease (CED) [MIM:131300]; also known as progressive diaphyseal dysplasia 1 (DPD1). CED is an autosomal dominant disorder characterized by hyperostosis and sclerosis of the diaphyses of long bones. The disease typically presents in early childhood with pain, muscular weakness and waddling gait, and in some cases other features such as exophthalmos, facial paralysis, hearing difficulties and loss of vision.
    SIMILARITY: SwissProt: P01137 ## Belongs to the TGF-beta family.
    产品使用声明
    质量保证 Routinely evaluated in an ATP endpoint assay.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    包装信息
    数量 1 µg


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