merck millipore,默克密理愽
  • merck millipore,默克密理博,AB2285,Anti-Glutamate Receptor Delta 1/2 Antibody

  • merck millipore,默克密理博,AB2285,Anti-Glutamate Receptor Delta 1/2 Antibody

    产品名称：Anti-Glutamate Receptor Delta 1/2 Antibody
    产品型号：AB2285
    Anti-Glutamate Receptor Delta 1/2 Antibody detects level of Glutamate Receptor Delta 1/2 & has been published & validated for use in WB.

    merck millipore,默克密理博,AB2285,Anti-Glutamate Receptor Delta 1/2 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB2285,Anti-Glutamate Receptor Delta 1/2 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, M, PmWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB2285
    描述 Anti-Glutamate Receptor Delta 1/2 Antibody
    Alternate Names
    • glutamate receptor, ionotropic, delta 1
    • GluR delta-1
    • glutamate receptor
    • ionotropic
    背景信息 The majority of rapid excitatory transmission in the nervous system is mediated by glutamate-activated ion channels. Ionotropic glutamate receptors have been subdivided pharmacologically into AMPA (cx-amino-3-hydroxy-5methyl-Cisoxazole propionic acid), KA (kainate), and NMDA subtypes (Monaghan et al., 1989). These receptors have been implicated in a number of physiological and pathological processes. During development glutamate receptors are involved in neuronal differentiation, migration, and activity-dependent synapse formation (Balazs et al., 1989; Brewer, 1989; Komoru and Rakic, 1993). In mature neurons, long-term potentiation and long-term depression require ionotropic glutamate receptors. Glutamate-gated ion channels also play a central role in mediating the excitotoxic effects of glutamate (Olney, 1990). Pathophysiological processes thought to involve glutamate excitotoxicity and neurodegeneration include epilepsy stroke, Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis.
    产品信息
    格式 Affinity Purified
    控制
    • Rat cerebellum tissue lysate and human cerebellum tissue lysate.
    演示 Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.
    应用
    应用 Anti-Glutamate Receptor Delta 1/2 Antibody detects level of Glutamate Receptor Delta 1/2 & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    应用说明 Western Blotting:
    Human Cerebellum Lysate.
    生物信息
    免疫原品种 Synthetic linear peptide to the C-Terminus, conjugated to BSA.
    表位 C-Terminus, Cytoplasmic
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Cat. # AB2285 reacts with the C-Terminus of Glutamate Receptor Delta 1/2.
    品种反应性 RatHumanMousePrimate
    Species Reactivity Note Proven to react with Rat and Human. Reacts weakly with mouse. May react with Primate based on sequence homology. Reactivity with other species has not been tested.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_017551.2
    Entrez基因汇总 This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.
    基因符号
    • OTTHUMP00000059648
    • GRID1
    • KIAA1220
    纯化方法 Antigen affinity purified
    UniProt编号
    • Q9ULK0
    UniProt汇总 FUNCTION: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein by similarity. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein by similarity.

    SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10) family.

    产品使用声明
    质量保证 Western Blotting: 1:5,000 dilution from a previous lot detected Glutamate Receptor Delta 1/2 on 10 µg of rat or human cerebellum lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8ºC from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB2285,Anti-Glutamate Receptor Delta 1/2 Antibody

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