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merck millipore,默克密理博,382173,Histone Deacetylase Inhibitor VII, 106 - CAS 937039-45-7 - Calbiochem
产品名称：Histone Deacetylase Inhibitor VII, 106 - CAS 937039-45-7 - Calbiochem
产品型号：382173
The Histone Deacetylase Inhibitor VII, 106, also referenced under CAS 937039-45-7, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Str More>>
merck millipore,默克密理博,382173,Histone Deacetylase Inhibitor VII, 106 - CAS 937039-45-7 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₀H₂₅N₃O₂ 937039-45-7 描述 概述 A cell-permeable p-tolylbenzamide and a Histone Deacetylase (HDAC) Inhibitor IV (Cat. No. 382170) analog that acts as a selective inhibitor against class I HDAC1,2,3 (IC50 = 0.15, 0.76, and 0.37 µM with 15, 30, and 180 min preincubation, respectively), while exhibiting much lower acitivity against class I HDAC8 (IC50 ≥ 5µM with 3 h preincubation) and no activity against class II HDAC4/5/7 even at concentrations as high as 180µM. Although the mode of inhibition is mechanistically competitive and reversible, due to the slow- and tight-binding nature, long preincubation is often required for effective in vitro enzyme inhibition, while 106-induced cellular H3 hyperacetylation is shown to persist for more than 6 hours after inhibitor removal by washing in GM15850 culture. 106 is reported to be less cytotoxic than TSA (Cat. No. 647925), MS-275, and SAHA (EC50 = 6.3, 0.328, 0.768, and 1.5 µM, respectively, in GM15850 killing). 产品目录编号 382173 品牌系列 Calbiochem®
同义词 N¹-(2-Aminophenyl)-N⁷-p-tolylheptanediamide, Pimelic Diphenylamide 106 参考 参考 Chou, C.J., et al. 2008. J. Biol. Chem. 283, 35402. 产品信息 CAS号 937039-45-7 形式 Yellow solid Hill配方 C₂₀H₂₅N₃O₂ 化学配方 C₂₀H₂₅N₃O₂ Molar Mass 339.4 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO or EtOH 安全信息 S相 S: 22-24/25-36
Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing.储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,IPFL10100,Immobilon-FL 方片膜，PVDF，0.45 µm，10 x 10 cm
下一件merck millipore产品：merck millipore,默克密理博,260585,5ʹ-Deoxy-5ʹ-methylthioadenosine - CAS 2457-80-9 - Calbiochem
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