merck millipore,默克密理愽
  • merck millipore,默克密理博,521238,PDGFRβ/RAF Kinase Inhibitor - Calbiochem

  • merck millipore,默克密理博,521238,PDGFRβ/RAF Kinase Inhibitor - Calbiochem

    产品名称：PDGFRβ/RAF Kinase Inhibitor - Calbiochem
    产品型号：521238
    The PDGFRβ/RAF Kinase Inhibitor controls the biological activity of PDGFRβ/RAF Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,521238,PDGFRβ/RAF Kinase Inhibitor - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,521238,PDGFRβ/RAF Kinase Inhibitor - Calbiochem

    重要规格表

    经验配方
    C₂₀H₁₆F₃N₇OS
    描述
    概述 An orally bioavailable amino-triazole compound that is shown to bind to the inactive conformations of both PDGFRβ and Raf kinases (allosteric, Type II inh), and acts as a potent inhibitor of Flt3, Kit, PDGFRα and PDGFRβ (Kd = 52, 170, 300 and 520 nM, respectively) with selectivity over B-Raf, p38α, FGFR2 and VEGFR2 (Kd > 10 µM) in a multi-kinase panel. Completely blocks the phosphorylations of MEK-1/2 S217/S221, ERK-1/2 T202/Y204 in FGF-stimulated HUVECs, PDGFRβ in PDGF-BB-stimulated VSMCs, ERK-1/2 T202/Y204 in 1205Lu-B Raf V600E cells, and C-Raf S338 at 10 µM. Reduces FGF-induced angiogenesis in mouse Matrigel model (50 mg/kg, i.p., bid) and selectively induces apoptosis in the endothelium; further, suppresses orthotopic renal cell carcinoma growth in mice (100 mg/kg, p.o., qd).
    产品目录编号 521238
    品牌系列 Calbiochem®
    同义词 6-(4-(5-(3-(Trifluoromethyl)phenylamino)-4 H-1,2,4-triazol-3-yl)phenoxy)-2-(methylthio)pyrimidin-4-amine , PDGFR Tyrosine Kinase Inhibitor XXII
    参考
    参考 Murphy, E.A., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 4299.
    产品信息
    形式 Beige solid
    Hill配方 C₂₀H₁₆F₃N₇OS
    化学配方 C₂₀H₁₆F₃N₇OS
    Molar Mass 459.6
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,521238,PDGFRβ/RAF Kinase Inhibitor - Calbiochem

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