merck millipore,默克密理愽
  • merck millipore,默克密理博,MABS475,Anti-GRP-78 Antibody, clone C107

  • merck millipore,默克密理博,MABS475,Anti-GRP-78 Antibody, clone C107

    产品名称：Anti-GRP-78 Antibody, clone C107
    产品型号：MABS475
    This Anti-GRP-78 Antibody, clone C107 is validated for use in western blotting, flow cytometry & Inhibits activity/Function for the detection of GRP-78.

    merck millipore,默克密理博,MABS475,Anti-GRP-78 Antibody, clone C107

  • 产品介绍
  • merck millipore,默克密理博,MABS475,Anti-GRP-78 Antibody, clone C107

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HFC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABS475
    描述 Anti-GRP-78 Antibody, clone C107
    Alternate Names
    • BiP
    • 78 kDa glucose-regulated protein
    • GRP-78
    • Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78
    • Heat shock 70 kDa protein 5
    • Immunoglobulin heavy chain-binding protein
    背景信息 The gene HSPA5 encodes a protein named GRP-78 (78 kDa glucose-regulated protein) also known as BiP (immunoglobulin heavy chain-binding protein) or heat shock 70 kDa protein 5. While originally discovered as one of set of genes that were induced upon cellular starvation and stress, HSPA5 encoded GRP-78 is now known to be an important member of the heat-shock family of proteins. The HSPA5 encoded GRP-78 protein appears to play a role in helping in the assembly of multimeric protein complexes in the endoplasmic reticulum (ER). Cellular localization is in the endoplasmic reticulum lumen and appears as cytoplasmic-like staining. The HSPA5 encoded protein is an essential component of the translocation processes within the endoplasmic reticulum and also functions in the retrograde transport across the ER membrane of incorrectly folded proteins destined to be degraded by the ubiquitin proteasome system. The HSPA5 encoded protein, while widely expressed in all cells types under normal conditions, is particularly induced under conditions of cellular stress, heat, or toxins and conditions which lead to the accumulation of unfolded proteins in the ER.
    产品信息
    格式 Purified
    演示 Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti-GRP-78 Antibody, clone C107 is validated for use in western blotting, flow cytometry & Inhibits activity/Function for the detection of GRP-78.
    主要应用
    • Flow Cytometry
    • Western Blotting
    应用说明 Western Blotting Analysis: 1 µg/mL from a representative lot detected GRP-78 in 10 µg of HeLa cell lysate.

    Flow Cytometry Analysis: A representative lot from an independent laboratory detected GRP-78 in B16F1 cells from tumor bearing mice (de Ridder, G. G., et al. (2012). Melanoma Res. 22(3):225-235.).

    Activity Assay Analysis: A representative lot from an independent laboratory reduces tumor growth in mice with B16F1 melanoma cells (de Ridder, G. G., et al. (2012). Melanoma Res. 22(3):225-235.).
    生物信息
    免疫原品种 Recombinant protein corresponding to human GRP-78.
    克隆 C107
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG2bκ
    品种反应性 MouseHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_005338
    基因符号
    • GRP78
    • HSPA5
    纯化方法 Protein G purified
    UniProt编号
    • P11021
    产品使用声明
    质量保证 Evaluated by Western Blotting in HepG2 cell lysate.

    Western Blotting Analysis: 1 µg/mL of this antibody detected GRP-78 in 10 µg of HepG2 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABS475,Anti-GRP-78 Antibody, clone C107

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