merck millipore,默克密理博,04-1048,Anti-MMP-2 Antibody, clone EP1183Y, rabbit monoclonal

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merck millipore,默克密理博,04-1048,Anti-MMP-2 Antibody, clone EP1183Y, rabbit monoclonal
产品名称：Anti-MMP-2 Antibody, clone EP1183Y, rabbit monoclonal
产品型号：04-1048
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-MMP-2 Antibody, clone EP1183Y, Rabbit is v More>>

merck millipore,默克密理博,04-1048,Anti-MMP-2 Antibody, clone EP1183Y, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-1048,Anti-MMP-2 Antibody, clone EP1183Y, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	WB	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	04-1048
描述	Anti-MMP-2 Antibody, clone EP1183Y, rabbit monoclonal
Alternate Names	neutrophil gelatinase 72 kDa gelatinase Gelatinase A Matrix metalloproteinase-2 collagenase type IV-A matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) matrix metalloproteinase 2 matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD type IV collagenase) matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) matrix metalloproteinase-II
背景信息	The matrix metalloproteinases (MMPs) are a family of secreted and membrane-bound zinc endopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non-fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, lupus, arthritis, periodontis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis. MMP2, also known as Gelatinase A, is a type IV collagenase that specifically cleaves type IV collagen, the major structural component of basement membranes. The metastatic potential of tumor cells has been found to correlate with the activity of this enzyme.

产品信息
格式	Unpurified
控制	Recombinant protein
演示	Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-MMP-2 Antibody, clone EP1183Y, Rabbit is validated for use in WB for the detection of MMP-2.
主要应用	Western Blotting

生物信息
免疫原品种	Synthetic peptide corresponding to residues on human MMP-2.
克隆	EP1183Y
宿主	Rabbit
特异性	This antibody detects both the pro- and active forms of MMP-2.
同种型	IgG
品种反应性	RatHumanMouse
Species Reactivity Note	Human, mouse, and rat.
抗体类型	Monoclonal Antibody
Entrez基因编号	P08253
基因符号	TBE-1 CLG4 CLG4A EC 3.4.24.24 MMP-2 MMP-II MONA
纯化方法	Unpurified
UniProt编号	P08253
UniProt汇总	FUNCTION: In addition to gelatin and collagens, it cleaves KiSS1 at a Gly-\|-Leu bond. CATALYTIC ACTIVITY: Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-\|-Ile-Ala-Gly-Gln. COFACTOR: Binds 4 calcium ions per subunit. Binds 2 zinc ions per subunit. ENZYME REGULATION: Inhibited by histatin-3 1/24 (histatin-5). SUBUNIT STRUCTURE: Ligand for integrin alpha-V/beta-3. SUBCELLULAR LOCATION: Secreted › extracellular space › extracellular matrix Probable. TISSUE SPECIFICITY: Produced by normal skin fibroblasts. DOMAIN: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. PTM: The propeptide is processed by MMP14 (MT-MMP1) and MMP16 (MT-MMP3). INVOLVEMENT IN DISEASE: Defects in MMP2 are the cause of Torg-Winchester syndrome [MIM:259600]; also called multicentric osteolysis nodulosis and arthropathy (MONA). Torg-Winchester syndrome is an autosomal recessive osteolysis syndrome. It is severe with generalized osteolysis and osteopenia. Subcutaneous nodules are usually absent. Torg-Winchester syndrome has been associated with a number of additional features including coarse face, corneal opacities, patches of thickened, hyperpigmented skin, hypertrichosis and gum hypertrophy. However, these features are not always present and have occasionally been observed in other osteolysis syndromes. SEQUENCE SIMILARITIES: Belongs to the peptidase M10A family. Contains 3 fibronectin type-II domains. Contains 4 hemopexin-like domains.

产品使用声明
质量保证	Evaluated by Western Blot using Anti-MMP-2. Western Blot Analysis: 1:1000 dilution of this antibody was used to detect MMP-2.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20ºC from date of receipt.

Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.