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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB2242 描述 Anti-SUR1/2 Antibody Alternate Names - SUR2
- ATP-binding cassette, sub-family C (CFTR/MRP), member 8
- ATP-binding cassette, sub-family C, member 8
- Sulfonylurea receptor 1
- sulfonylurea receptor (hyperinsulinemia)
- SUR1 <br />ATP-binding cassette, sub-family C (CFTR/MRP), member 9
- ATP-binding cassette, sub-family C, member 9
- Sulfonylurea receptor 2
- sulfonylurea receptor 2A
背景信息 The protein encoded by the SUR1 (SUR2) genes is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. These genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The SUR1/2 protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and smooth muscle (both vascular and non-vascular). No disease has been associated with this gene thus far. Alternative splicing of this gene results in several products, two of which result from differential usage of two terminal exons and one of which results from exon deletion. 产品信息 格式 Affinity Purified 控制 - Rat pancreas tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect SUR1/2 using this Anti-SUR1/2 Antibody validated for use in WB. 主要应用 - Western Blotting
应用说明 n/a 生物信息 免疫原品种 This antibody is generated from rabbits immunized with a KLH-conjugated linear peptide corresponding to residues surrounding the cytoplasmic domain of human SUR1/2. 表位 Cytoplasmic Domain 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes SUR1/2. 品种反应性 RatMouse Species Reactivity Note Predicted to react with human, cow, horse, opossum, and chimpanzee based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_005682 (SUR2)
Entrez基因汇总 The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extrapancreatic ATP-sensitive potassium channels. No disease has been associated with this gene thus far. Alternative splicing of this gene results in several products, two of which result from differential usage of two terminal exons and one of which results from exon deletion. [provided by RefSeq] 基因符号 - SUR2
- ABCC8
- ABC36
- MRP8
- SUR
- SUR1
- ABCC9
- ABC37
- CMD10
纯化方法 Affinity Purfied UniProt编号 - Q09428 (SUR1)
UniProt汇总 FUNCTION: Putative subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K+ channels and insulin release.
SUBUNIT STRUCTURE: Associates with KCNJ11.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
INVOLVEMENT IN DISEASE: Defects in ABCC8 are a cause of leucine-induced hypoglycemia (LIH) [MIM:240800]; also called leucine-sensitive hypoglycemia of infancy. LIH is a rare cause of hypoglycemia and is described as a condition in which symptomatic hypoglycemia is provoked by high protein feedings. Hypoglycemia is also elicited by administration of oral or intravenous infusions of a single amino acid, leucine.
DEFECTS: in ABCC8 are the cause of familial hyperinsulinemic hypoglycemia type 1 (HHF1) [MIM:256450]; also known as persistent hyperinsulinemic hypoglycemia of infancy (PHHI) or hyperinsulinism. HHF1 is the most common cause of persistent hypoglycemia in infancy and is due to defective negative feedback regulation of insulin secretion by low glucose levels. It causes nesidioblastosis, a diffuse abnormality of the pancreas in which there is extensive, often disorganized formation of new islets. Unless early and aggressive intervention is undertaken, brain damage from recurrent episodes of hypoglycemia may occur.
Defects in ABCC8 are a cause of permanent neonatal diabetes mellitus (PNDM) [MIM:606176]; also called permanent diabetes mellitus of infancy (PDMI). PNDM is a rare form of diabetes characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.
Defects in ABCC8 are the cause of transient neonatal diabetes mellitus type 2 (TNDM2) [MIM:610374]. Neonatal diabetes is a form of diabetes mellitus defined by the onset of mild-to-severe hyperglycemia within the first months of life. Transient neonatal diabetes remits early, with a possible relapse during adolescence.
Defects in ABCC8 may contribute to non-insulin-dependent diabetes mellitus (NIDDM), also known as diabetes mellitus type 2, in Northern European Caucasians.
SEQUENCE SIMILARITIES: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]
Contains 2 ABC transmembrane type-1 domains.
Contains 2 ABC transporter domains.产品使用声明 质量保证 Evaluated by Western Blot in rat pancreas lysate.
Western Blot Analysis: : 1 µg/ml of this antibody detected SUR1/2 on 10 µg of rat pancreas lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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