merck millipore,默克密理愽
  • merck millipore,默克密理博,CBL196,Anti-Cytokeratin 10 Antibody, clone LH-2

  • merck millipore,默克密理博,CBL196,Anti-Cytokeratin 10 Antibody, clone LH-2

    产品名称：Anti-Cytokeratin 10 Antibody, clone LH-2
    产品型号：CBL196
    Detect Cytokeratin 10 using this Anti-Cytokeratin 10 Antibody, clone LH-2 validated for use in WB, IH(P).

    merck millipore,默克密理博,CBL196,Anti-Cytokeratin 10 Antibody, clone LH-2

  • 产品介绍
  • merck millipore,默克密理博,CBL196,Anti-Cytokeratin 10 Antibody, clone LH-2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 CBL196
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Cytokeratin 10 Antibody, clone LH-2
    产品信息
    格式 Purified
    演示 The monoclonal is presented at a concentration of 100μg/1ml in phosphate buffered saline containing 10mM sodium azide and 1% bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application.
    应用
    应用 Detect Cytokeratin 10 using this Anti-Cytokeratin 10 Antibody, clone LH-2 validated for use in WB, IH(P).
    主要应用
    • Western Blotting
    应用说明 Identification of cytokeratin expressing cells by indirect immmunoperoxidase staining of frozen sections

    Western blotting

    IHC - formalin fixed sections. Pretreatment with type XXIV protease (0.5mg/ml) produces best results.

    Optimal working dilutions must be determined by the end user.
    生物信息
    克隆 LH-2
    宿主 Mouse
    特异性 The antibody reacts specifically with human cytokeratin 10 found in suprabasal cells of stratified squamous epithelia.
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000421.2
    Entrez基因汇总 This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21.
    基因符号
    • CK10
    • KRT10
    • K10
    • CK-10
    • Keratin-10
    • Cytokeratin-10
    • KPP
    UniProt编号
    • P13645
    UniProt汇总 SIZE: 593 amino acids; 59511 Da
    SUBUNIT: Heterotetramer of two type I and two type II keratins. keratin-10 is generally associated with keratin-1.
    TISSUE SPECIFICITY: Seen in all suprabasal cell layers including stratum corneum.
    DISEASE: SwissProt: P13645 # Defects in KRT10 are a cause of epidermolytic hyperkeratosis (EHK) [MIM:113800]; also known as bullous congenital ichthyosiform erythroderma (BCIE) or bullous erythroderma ichthyosiformis congenita of Brocq. EHK is an hereditary skin disorder characterized by blistering and a marked thickening of the stratum corneum. At birth, affected individuals usually present with redness, blisters and superficial erosions due to cytolysis. Within a few weeks, the erythroderma and blister formation diminish and hyperkeratoses develop. Transmission is autosomal dominant, but most cases are sporadic. & Defects in KRT10 are a cause of annular epidermolytic ichthyosis (AEI) [MIM:607602]; also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI resembles clinical and histologic features of both epidermolytic hyperkeratosis and ichthyosis bullosa of Siemens. & Defects in KRT10 are a cause of epidermal nevus epidermolytic hyperkeratotic type [MIM:600648]. Epidermal nevi affect about 1 in 1,000 people. They appear at or shortly after birth as localized lines of epidermal thickening. The extent of skin involvement varies widely.
    SIMILARITY: SwissProt: P13645 ## Belongs to the intermediate filament family.
    MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,CBL196,Anti-Cytokeratin 10 Antibody, clone LH-2

上一件merck millipore产品：merck millipore,默克密理博,04-1071,Anti-SynGAP (CT) Antibody, clone EPR2883Y, rabbit monoclonal
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