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merck millipore,默克密理博,04-1071,Anti-SynGAP (CT) Antibody, clone EPR2883Y, rabbit monoclonal
产品名称：Anti-SynGAP (CT) Antibody, clone EPR2883Y, rabbit monoclonal
产品型号：04-1071
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect SynGAP (C-term) using this Anti-SynGAP (C-ter More>>
merck millipore,默克密理博,04-1071,Anti-SynGAP (CT) Antibody, clone EPR2883Y, rabbit monoclonal
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M FC, WB Rb Unpurified Monoclonal Antibody 描述 产品目录编号 04-1071 描述 Anti-SynGAP (CT) Antibody, clone EPR2883Y, rabbit monoclonal Alternate Names - synaptic Ras GTPase activating protein, 135kDa
- Neuronal RasGAP
- Synaptic Ras GTPase-activating protein 1
- Synaptic Ras-GAP 1
- synaptic Ras GTPase activating protein 1
- synaptic Ras GTPase activating protein 1 (homolog of rat)
- synaptic Ras GTPase activating protein 1 homolog (rat)
背景信息 Silent synapses, or excitatory synapses that lack functional α- amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), are thought to be critical for regulation of neuronal circuits and synaptic plasticity. SynGAP, an excitatory synapse-specific RasGAP, regulates AMPAR trafficking, silent synapse number, and excitatory synaptic transmission in hippocampal and cortical cultured neurons. Over expression of SynGAP in neurons results in a remarkable depression of AMPAR-mediated miniature excitatory postsynaptic currents, a significant reduction in synaptic AMPAR surface expression, and a decrease in the insertion of AMPARs into the plasma membrane. Synaptic transmission is increased in neurons from SynGAP knockout mice as well as in neuronal cultures treated with SynGAP small interfering RNA. 产品信息 格式 Unpurified 控制 - Fetal brain lysate
演示 Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. 应用 应用 Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect SynGAP (C-term) using this Anti-SynGAP (C-term) Antibody, clone EPR2883Y, Rabbit validated for use in WB, FC. 主要应用 - Flow Cytometry
- Western Blotting
应用说明 Flow Cytometry: A 1:50 dilution of a previous lot was used in flow cytometry. 生物信息 免疫原品种 Synthetic peptide corresponding to residues on the C-terminus of human SynGAP. 表位 C-terminus 克隆 EPR2883Y 宿主 Rabbit 特异性 This antibody recognizes SynGAP at and around the C-terminus. 同种型 IgG 品种反应性 RatHumanMouse Species Reactivity Note Human, mouse, and rat. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_006763.2
基因符号 - SYNGAP
- DKFZp761G1421
- KIAA1938
- MRD5
- OTTHUMP00000064825
- RASA1
- RASA5
纯化方法 Unpurified UniProt编号 - Q96PV0
UniProt汇总 FUNCTION: Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits By similarity.
SUBUNIT STRUCTURE: Interacts CAMK2A and CAMK2B By similarity. Interacts with MPDZ.
PTM: Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption By similarity.
INVOLVEMENT IN DISEASE: Defects in SYNGAP1 are the cause of mental retardation autosomal dominant type 5 (MRD5) [MIM:612621]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRD5 patients show global developmental delay with delayed motor development, hypotonia, moderate-to-severe mental retardation, and severe language impairment.
SEQUENCE SIMILARITIES: Contains 1 C2 domain.
Contains 1 PH domain.
Contains 1 Ras-GAP domain.
Caution It is uncertain whether Met-1 or Met-16 is the initiator methionine.产品使用声明 质量保证 Evaluated by Western Blot on fetal brain cell lysates.
Western Blot Analysis: 1:1,000-5,000 dilution of this antibody was used to detect SynGAP in fetal brain cell lysate.
使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20ºC from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.包装信息 数量 100 µL
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