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![merck millipore,默克密理博,AB1929,Anti-Integrin β1 Antibody, phospho-specific [Thr788/Thr789]](/e/upload/m_pic/Antibody_STD%5BAntibody_STD-ALL%5D.jpg "merck millipore,默克密理博,AB1929,Anti-Integrin β1 Antibody, phospho-specific [Thr788/Thr789]")
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merck millipore,默克密理博,AB1929,Anti-Integrin β1 Antibody, phospho-specific [Thr788/Thr789]
产品名称：Anti-Integrin β1 Antibody, phospho-specific [Thr788/Thr789]
产品型号：AB1929
Anti-Integrin β1 Antibody, phospho-specific [Thr788/Thr789] is an antibody against Integrin β1 for use in WB.
merck millipore,默克密理博,AB1929,Anti-Integrin β1 Antibody, phospho-specific [Thr788/Thr789]
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB1929 Replaces 04-1109 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Integrin β1 Antibody, phospho-specific [Thr788/Thr789] Alternate Names - Fibronectin receptor subunit beta
- CD29
- Integrin VLA-4 subunit beta
背景信息 Integrin beta1 is a transmembrane glycoprotein that forms noncovalent complexes with various alpha integrin subunits to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumor cells. Interactions between integrins and extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. Phosphorylation of threonines 788 and 789 on integrin beta1 receptor may play a key role in cell-cycle dependent regulation. 产品信息 格式 Affinity Purified 演示 Antibody is cross-adsorbed to nonphospho-peptide corresponding to the site of phosphorylation then affinity purified using phosphorylated integrin beta1 receptor (Thr788/789) peptide. Antibody is supplied in Dulbecco's phosphate-buffered saline (without Mg2+ or Ca2+), pH 7.3, 50% glycerol and 1 mg/mL BSA. 应用 应用 Anti-Integrin β1 Antibody, phospho-specific [Thr788/Thr789] is an antibody against Integrin β1 for use in WB. 主要应用 - Western Blotting
应用说明 Western Blot: 1:1000.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Phosphorylated synthetic peptide corresponding to amino acid residues surrounding and including threonine 788/789 of the human beta1 integrin. The immunogen sequence is 100% identical in mouse, rat and chicken integrin beta1. 表位 pT788/789 宿主 Rabbit 特异性 The antibody detects a 130 kDa protein of integrin beta1 receptor. 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_133376.1
- NM_002211.2
- NM_033666.1
- NM_033667.1
- NM_033668.1
- NM_033669.1
Entrez基因汇总 Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. 基因符号 - MSK12
- ITGB1
- GPIIA
- OTTHUMP00000063731
- OTTHUMP00000046253
- OTTHUMP00000063733
- VLAB
- OTTHUMP00000063732
- MDF2
- FNRB
- CD29
修改 - Phosphorylation
纯化方法 Immunoaffinity purified UniProt编号 - P05556
UniProt汇总 FUNCTION: SwissProt: P05556 # Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha- 3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha- 10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
SIZE: 798 amino acids; 88465 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha- 5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Interacts with FLNA. Binds LGALS3BP and ITGB1BP3, when associated with alpha-7, but not with alpha-5 (By similarity). Interacts with FLNB and RANBP9. Isoform Beta-1D interacts with ACE2. Isoform Beta-1A interacts with the C-terminal region of FLNC. Interacts with HIV-1 Tat.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Isoform beta-1B does not localize to focal adhesions. Highly enriched in stage I melanosomes.
TISSUE SPECIFICITY: Isoform beta-1A is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform beta-1B is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbelical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform beta-1C and isoform beta-1C-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-C-2, rather than isoform beta-1C, is selectively expressed in primary T-cells. Isoform beta-1C is expressed in nonproliferating and differentiated prostate gland epithelial cells. Isoform beta-1D is expressed specifically in striated muscle (skeletal and cardiac muscle).
SIMILARITY: SwissProt: P05556 ## Belongs to the integrin beta chain family. & Contains 1 VWFA domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C for up to one year from date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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