merck millipore,默克密理愽
  • merck millipore,默克密理博,05-588,Anti-HET/SAF-B Antibody, clone 6F7

  • merck millipore,默克密理博,05-588,Anti-HET/SAF-B Antibody, clone 6F7

    产品名称：Anti-HET/SAF-B Antibody, clone 6F7
    产品型号：05-588
    Anti-HET/SAF-B Antibody, clone 6F7 is a high quality Mouse Monoclonal Antibody for the detection of HET/SAF-B & has been validated in IP, WB, ICC & IHC.

    merck millipore,默克密理博,05-588,Anti-HET/SAF-B Antibody, clone 6F7

  • 产品介绍
  • merck millipore,默克密理博,05-588,Anti-HET/SAF-B Antibody, clone 6F7

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, WB, ICCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-588
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-HET/SAF-B Antibody, clone 6F7
    产品信息
    格式 Purified
    演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
    应用
    应用 Anti-HET/SAF-B Antibody, clone 6F7 is a high quality Mouse Monoclonal Antibody for the detection of HET/SAF-B & has been validated in IP, WB, ICC & IHC.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    • Immunocytochemistry
    生物信息
    免疫原品种 Peptide corresponding to residues 345-357 of human HET/SAF-B
    克隆 clone 6F7
    宿主 Mouse
    特异性 HET/SAF-B
    同种型 IgG
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002555
    Entrez基因汇总 This gene encodes a DNA-binding protein that has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. This encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of the heat shock protein 27 transcription and also can act as an estrogen receptor corepressor. This gene is a candidate gene for breast tumorigenesis.
    基因符号
    • SAFB1
    • SAFB
    • HET
    • DKFZp779C1727
    • HAP
    • SAF-B
    纯化方法 Protein G chromatography
    UniProt编号
    • Q15424
    UniProt汇总 FUNCTION: SwissProt: Q15424 # Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. Can inhibit cell proliferation.
    SIZE: 915 amino acids; 102642 Da
    SUBUNIT: Monomer. Can form homodimers. Interacts with KHDRBS3, POLR2A, SAFB2 or SFRS1, SFRS9 and SFRS10 (By similarity).
    SUBCELLULAR LOCATION: Nucleus.
    TISSUE SPECIFICITY: Ubiquitous. Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines.
    SIMILARITY: SwissProt: Q15424 ## Contains 1 RRM (RNA recognition motif) domain. & Contains 1 SAP domain.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on whole cell extracts or RIPA lysates from MCF-7 cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 200 µg

    merck millipore,默克密理博,05-588,Anti-HET/SAF-B Antibody, clone 6F7

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