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merck millipore,默克密理博,AB1923,Anti-Integrin αV Antibody, cytoplasmic domain
产品名称:Anti-Integrin αV Antibody, cytoplasmic domain
产品型号:AB1923
Anti-Integrin αV Antibody, cytoplasmic domain detects level of Integrin αV & has been published & validated for use in ELISA & WB.
merck millipore,默克密理博,AB1923,Anti-Integrin αV Antibody, cytoplasmic domain
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB, ELISA Rb Serum Polyclonal Antibody 描述 产品目录编号 AB1923 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Integrin αV Antibody, cytoplasmic domain Alternate Names - CD51 Antigen
- Vitronectin Receptor alpha Subunit
产品信息 格式 Serum 演示 Whole rabbit serum. Liquid containing no preservative 应用 应用 Anti-Integrin αV Antibody, cytoplasmic domain detects level of Integrin αV & has been published & validated for use in ELISA & WB. 主要应用 - Western Blotting
- ELISA
应用说明 ELISA: 1:500 (direct)
Western Blot: 1:500. Antibody detects a non-reducible 155 kDa band corresponding to integrin alphaV.
Optimal dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide corresponding to amino acids 1035-1048 of human integrin alphaV. This peptide sequence is absolutely conserved in the mouse integrin alphaV sequence. 表位 cytoplasmic domain 宿主 Rabbit 特异性 Integrin alphaV 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002210.2
Entrez基因汇总 ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. 基因符号 - VNRA
- ITGAV
- DKFZp686A08142
- MSK8
- CD51
UniProt编号 - P06756
UniProt汇总 FUNCTION: SwissProt: P06756 # The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
SIZE: 1048 amino acids; 116038 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P06756 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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