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  • merck millipore,默克密理博,MAB5478,Anti-Retinoid X Receptor α Antibody

  • merck millipore,默克密理博,MAB5478,Anti-Retinoid X Receptor α Antibody

    产品名称：Anti-Retinoid X Receptor α Antibody
    产品型号：MAB5478
    Use Anti-Retinoid X Receptor α Antibody (Mouse Monoclonal Antibody) validated in ELISA, EMSA, IP, WB to detect Retinoid X Receptor α also known as RXR alpha.

    merck millipore,默克密理博,MAB5478,Anti-Retinoid X Receptor α Antibody

  • 产品介绍
  • merck millipore,默克密理博,MAB5478,Anti-Retinoid X Receptor α Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWB, ELISA, EMSAMAscitesMonoclonal Antibody
    描述
    产品目录编号 MAB5478
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Retinoid X Receptor α Antibody
    Alternate Names
    • RXRalpha
    产品信息
    格式 Ascites
    演示 Ascites fluid. Liquid. Contains no preservative.
    应用
    应用 Use Anti-Retinoid X Receptor α Antibody (Mouse Monoclonal Antibody) validated in ELISA, EMSA, IP, WB to detect Retinoid X Receptor α also known as RXR alpha.
    主要应用
    • Western Blotting
    • ELISA
    • Electrophoretic Mobility Shift Assay
    应用说明 Western blot (endogenous and recombinant protein): 1:500-1:5,000

    Immunocytochemistry (transfected cells): 1:500-1:5,000

    Immunoprecipitation (endogenous and recombinant protein): 1:500-1:5,000

    Gel shift (endogenous and recombinant protein): 1:500-1:5,000

    ELISA: 1:500-1:5,000

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Fusion protein corresponding to the DE-region of mouse RXRa.
    宿主 Mouse
    特异性 Reacts with Retinoid X Receptor alpha (RXRalpha). No cross reactivity with RXRbeta or RXRgamma.
    同种型 IgG1
    品种反应性 MouseHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002957.3
    Entrez基因汇总 Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators.
    基因符号
    • MGC102720
    • RXRA
    • FLJ16020
    • FLJ16733
    • NR2B1
    UniProt编号
    • P19793
    UniProt汇总 FUNCTION: SwissProt: P19793 # Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA). ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer (By similarity).
    SIZE: 462 amino acids; 50811 Da
    SUBUNIT: Homodimer or forms a heterodimer with peroxisome proliferator activated receptor gamma called adipocyte-specific transcription factor ARF6. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes (By similarity). Interacts with SFPQ. Interacts with HCV core protein. Interacts with PELP1. Interacts with SENP6.
    SUBCELLULAR LOCATION: Nucleus.
    TISSUE SPECIFICITY: Highly expressed in liver, also found in lung, kidney and heart.
    DOMAIN: SwissProt: P19793 Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.
    PTM: Sumoylated on Lys-108; which negatively regulates transcriptional activity. Desumoylated specifically by SENP6.
    SIMILARITY: Belongs to the nuclear hormone receptor family. NR2 subfamily. & Contains 1 nuclear receptor DNA-binding domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MAB5478,Anti-Retinoid X Receptor α Antibody

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