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品种反应性 主要应用 宿主 格式 抗体类型 H ELISA Rb Serum Polyclonal Antibody 描述 产品目录编号 AB1858 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Osteonectin Antibody Alternate Names - SPARC
背景信息 Osteonectin is one of the major noncollagenous proteins in the extracellular matrix of bone. It is a glycoprotein with a molecular weight of 43 kDa and has calcium-binding properties. 产品信息 格式 Serum 演示 Rabbit serum. Lyophilized. Reconstitute with 100 μL of sterile distillled water. 应用 应用 Anti-Osteonectin Antibody is an antibody against Osteonectin for use in ELISA, IH(P). 主要应用 - ELISA
应用说明 ELISA (1:5,000)
Immunohistochemistry on paraffin-embedded tissue sections (1:1,000)
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 recombinant osteonectin expressed in human embryonal kidney line HEK-293. 宿主 Rabbit 特异性 Human Osteonectin (ON). 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_003118.2
Entrez基因汇总 Secreted protein acidic and rich in cysteine/osteonectin/BM40, or SPARC, is a matrix-associated protein that elicits changes in cell shape, inhibits cell-cycle progression, and influences the synthesis of extracellular matrix (ECM) (Bradshaw et al., 2003 [PubMed 12721366]).[supplied by OMIM] 基因符号 - ON
- SPARC
- Osteonectin
- BM-40
UniProt编号 - P09486
UniProt汇总 FUNCTION: SwissProt: P09486 # Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
SIZE: 303 amino acids; 34632 Da
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
DEVELOPMENTAL STAGE: Expressed at high levels in tissues undergoing morphogenesis, remodeling and wound repair.
SIMILARITY: SwissProt: P09486 ## Belongs to the SPARC family. & Contains 1 EF-hand domain. & Contains 1 follistatin-like domain. & Contains 1 Kazal-like domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain lyophilized material at -20°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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