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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB M Purified Monoclonal Antibody 描述 产品目录编号 04-486 品牌系列 Upstate
商名 - Upstate
描述 Anti-RhoG Antibody, clone 1F3 B3 E5 Alternate Names - MGC125836
- ARHG
- RHOG ras homolog gene family, member G (rho G)
- MGC125835
- MGC125835
背景信息 RhoG (ARGH) is a member of the Ras super-family of small G-proteins and a member of the Rac subfamily of Rho Family of GTPases. RhoG is a small G-protein (GTPase) who is activated by a GEF (guanine nucleotide exchange factor). The GEF displaces GDP from the binding site of RhoG and allows GTP to bind in it place rendering the protein active. This active RhoG binds downstream effector molecules that include ELMO and DOCK180. RhoG then cleaves GTP to GDP making it inactive. RhoG is believed to be crucial for integrin-mediated Rac activation and cell spreading. RhoG is believed to be active upstream of Rac and work independently of Rac. 产品信息 格式 Purified 演示 Purified mouse monoclonal IgG2b in storage buffer containing PBS with 0.05% sodium azide. 应用 应用 Anti-RhoG Antibody, clone 1F3 B3 E5 is an antibody against RhoG for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH synthetic peptide encompassing amino acids CQQDGVKEVFAEAVRAVLNPT (RhoG 160-180) 克隆 clone 1F3 B3 E5 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Recognizes RhoG 同种型 IgG2bκ 品种反应性 RatHumanMouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_001665
Entrez基因汇总 ARHG is a member of the RAS superfamily of genes, which encode GTP-binding proteins that act in the pathway of signal transduction and play a key role in the regulation of cellular functions.[supplied by OMIM] 基因符号 - MGC125836
- RHOG ras homolog gene family, member G (rho G)
- Rho G
- ARHG
- MGC125835
纯化方法 Protein G purfied UniProt编号 - P84095
UniProt汇总 FUNCTION: Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.
SUBUNIT STRUCTURE:Interacts with SGEF.
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic sidePotential.
Sequence similarities: Belongs to the small GTPase superfamily. Rho family.产品使用声明 质量保证 Routinely evaluated by western blot on NIH/3T3 cell lysate. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at 2-8°C.包装信息 数量 100 µg
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