merck millipore,默克密理愽
  • merck millipore,默克密理博,219674,InSolution™ CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem

  • merck millipore,默克密理博,219674,InSolution™ CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem

    产品名称：InSolution™ CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem
    产品型号：219674
    The InSolution™ CFTR Inhibitor-172, also referenced under CAS 307510-92-5, controls the biological activity of CFTR. This small molecule/inhibitor is primarily used for Biochemicals applications.

    merck millipore,默克密理博,219674,InSolution™ CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,219674,InSolution™ CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₈H₁₀F₃NO₃S₂307510-92-5
    描述
    概述 A cell-permeable 2-thio-4-thiazolidinone compound that acts as a potent, reversible, rapid, and voltage-independent inhibitor of CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl- transport in human airway cells (Ki ~ 300 nM). It does not prevent elevation of cellular cAMP, nor does it inhibit non-CFTR Cl- channels, MDR-1, ATP-sensitive K+ channels, or a series of other transporters even at concentrations as high as 5 µM. Shown to block cholera toxin-induced intestinal fluid secretion in mice. May be also useful for reducing intestinal fluid loss in other secretory diarrheas. The solid form of this compound (Cat. No. 219670) is also available.
    产品目录编号 219674
    品牌系列 Calbiochem®
    同义词 (Z)-4-((4-Oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid, CFTRinh-172 in DMSO, 3-((3-Trifluoromethyl)phenyl)-5-((4-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone
    参考
    参考 Yang, H., et al. 2003. J. Biol. Chem. 278, 35079.
    Al-Awqati, Q., et al. 2002. J. Clin. Invest. 110, 1599.
    Ma, T., et al. 2002. J. Clin. Invest. 110, 1651.
    产品信息
    CAS号 307510-92-5
    形式 Liquid
    配方 A 50 mM (5 mg/244 µL) solution of CFTR Inhibitor-172 (Cat. No. 219670) in DMSO.
    Hill配方 C₁₈H₁₀F₃NO₃S₂
    Molar Mass 409.4
    吸湿 Hygroscopic
    可逆 Y
    结构配方图像
    生物信息
    主靶 CFTR ion-channel
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    安全信息
    R相 R: 36/38

    Irritating to eyes and skin.
    S相 S: 26-36/37/39

    In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    Wear suitable protective clothing, gloves and eye/face protection.
    储存和货运信息
    货运代码 Dry Ice Only
    毒性 Irritant
    储存 ≤ -70°C
    避光 Protect from light
    吸湿 Hygroscopic
    避免冻结 / 解冻 Avoid freeze/thaw
    无需冷冻 No
    特殊指南 Following initial thaw, aliquot and freeze (70°C). Aliquots are stable for up to 3 months at -70°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,219674,InSolution™ CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem

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