merck millipore,默克密理愽
  • merck millipore,默克密理博,CBL1512F,Anti-Integrin αM [CD11b] Antibody, clone OX-42, FITC conjugated

  • merck millipore,默克密理博,CBL1512F,Anti-Integrin αM [CD11b] Antibody, clone OX-42, FITC conjugated

    产品名称：Anti-Integrin αM [CD11b] Antibody, clone OX-42, FITC conjugated
    产品型号：CBL1512F
    This Anti-Integrin αM [CD11b] Antibody, clone OX-42, FITC conjugated is validated for use in FC, IH for the detection of Integrin αM [CD11b].

    merck millipore,默克密理博,CBL1512F,Anti-Integrin αM [CD11b] Antibody, clone OX-42, FITC conjugated

  • 产品介绍
  • merck millipore,默克密理博,CBL1512F,Anti-Integrin αM [CD11b] Antibody, clone OX-42, FITC conjugated

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    RIHC, FCMFITCMonoclonal Antibody
    描述
    产品目录编号 CBL1512F
    Replaces MAB1404F
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Integrin αM [CD11b] Antibody, clone OX-42, FITC conjugated
    Alternate Names
    • CD11b
    产品信息
    格式 FITC
    演示 The conjugate is supplied as a 100 test/1 mL vial in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. For flow cytometry we recommend using 10μL of conjugate per test.
    应用
    应用 This Anti-Integrin αM [CD11b] Antibody, clone OX-42, FITC conjugated is validated for use in FC, IH for the detection of Integrin αM [CD11b].
    主要应用
    • Immunohistochemistry
    • Flow Cytometry
    应用说明 Flow cytometry

    Immunohistochemical studies of rat fresh frozen tissue sections following either periodate-lysine-paraformaldehyde (PLP) fixation, or acetone. Works on very lightly PFA fixed, frozen tissues. (perfusion only 4% PFA 10-15' no post-fix).

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Rat peritoneal macrophages
    克隆 OX-42
    宿主 Mouse
    特异性 This antibody recognizes most macrophages (including resident peritoneal and activated macrophages), kupffer cells, but only about 35% of alveolar macrophages. The antibody also labels dendritic cells extensively, granulocytes and cells with the morphology of microglia in brain. The antibody precipitates three polypeptides of 150, 103 and 95 KDa. The antibody inhibits complement mediated rosettes and is probably the rat equivalent of the human receptor for IC3b called CR3.
    FUSION PARTNER: NSO myeloma cell line.
    同种型 IgG2a
    品种反应性 Rat
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000632.3
    Entrez基因汇总 This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Some integrin alpha M proteins contain an inserted amino acid (Q, between AA positions 499 and 500) resulting from a 3bp shift in a splice acceptor that inserts the codon CAG; receptors with or without the extra amino acid are functionally indistinguishable
    基因符号
    • MGC117044
    • ITGAM
    • MO1A
    • CD11b
    • MAC1A
    • CD11B
    • MAC-1
    • CR3A
    UniProt编号
    • P11215
    UniProt汇总 FUNCTION: SwissProt: P11215 # Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
    SIZE: 1152 amino acids; 127179 Da
    SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    TISSUE SPECIFICITY: Predominantly expressed in monocytes and granulocytes.
    DOMAIN: SwissProt: P11215 The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
    SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. & Contains 1 VWFA domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Store at +4°C protected from light. DO NOT FREEZE. For long term use and storage aliquot conjugate into small volumes and store at +4°C.
    包装信息
    数量 100 assays

    merck millipore,默克密理博,CBL1512F,Anti-Integrin αM [CD11b] Antibody, clone OX-42, FITC conjugated

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