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品种反应性 主要应用 宿主 格式 抗体类型 R, Av, H, Mi, M IP M Gel Immobilized Monoclonal Antibody 描述 产品目录编号 16-186 品牌系列 Upstate
商名 - Upstate
描述 Anti-Src Antibody, clone GD11, agarose 产品信息 格式 Gel Immobilized 演示 PBS, pH 7.1, containing 0.1% sodium azide. 应用 应用 Anti-Src Antibody, clone GD11, agarose is an antibody against Src for use in IP. 主要应用 - Immunoprecipitation
生物信息 克隆 clone GD11 宿主 Mouse 品种反应性 RatAvianHumanMinkMouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_198291.1
- NM_005417.3
Entrez基因汇总 This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. 基因符号 - pp60c-src
- SRC
- c-src
- p60-Src
- SRC1
- c-SRC
- ASV
UniProt编号 - P12931
UniProt汇总 SIZE: 536 amino acids; 59835 Da
SUBUNIT: Interacts with DDEF1/ASAP1 via its SH3 domain. Interacts with CCPG1 (By similarity). Interacts with CDCP1, PELP1, TGFB1I1 and TOM1L2.
PTM: Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. The phosphorylated tail interacts with the SH2 domain thereby repressing kinase activity.
SIMILARITY: SwissProt: P12931 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.产品使用声明 质量保证 Routinely evaluated by immunoprecipitation of Src from EGF-stimulated A431 RIPA lysate and detected by western immunoblot analysis, using anti-Src, clone GD11 (05-184). 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at 4°C 包装信息 数量 200 µg
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