merck millipore,默克密理博,14-856,Ubiquitin C-terminal hydrolase L3 (UCH-L3), 50 µg

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

Entrez基因编号	品种	Uni Prot编号
NM_006002.3	Human	P15374

描述
产品目录编号	14-856
品牌系列	Upstate
商名	Upstate
描述	Ubiquitin C-terminal hydrolase L3 (UCH-L3), 50 µg
概述	Produced from human cDNA, expressed in E. coli. Ubiquitin C-terminal hydrolases (UCHs) are a family of cysteine hydrolases that catalyze the hydrolysis of amides, esters and thioesters of the C-terminus of ubiquitin. UCH-L3 is a member of the lower molecular weight group of UCHs involved in the hydrolysis of small C-terminal derivatives of ubiquitin that form non-specifically during the process of protein ubiquitinylation.

应用
应用	From human cDNA, expressed in E. coli. Ubiquitin C-terminal hydrolases are a family of cysteine hydrolases that catalyze the hydrolysis of amides, esters & thioesters of the C-terminus of ubiquitin.

生物信息
来源	Recombinant human UCH-L3 expressed in E.coli.
品种	Human
特异活性	>1000 pmol/min/μg. Determined at 25°C with 1 μM ubiquitin-AMC as substrate and UCH-L3 at 20 pM (0.58 ng/mL).
Entrez基因编号	NM_006002.3
基因符号	UCHL3
UniProt编号	P15374
UniProt汇总	FUNCTION: SwissProt: P15374 # Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. SIZE: 230 amino acids; 26183 Da SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, and testis. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. DISEASE: SwissProt: P15374 # A defect or alteration in the expression of enzymes catalyzing the removal of ubiquitin from ubiquitin-proteins conjugates may be a characteristic of neurodegenerative diseases such as Alzheimer disease, Parkinson disease, progressive supranuclear palsy, and Pick and Kuf disease. & Identified as a tumor-specific antigen in colon cancer. SIMILARITY: SwissProt: P15374 ## Belongs to the peptidase C12 family.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Store at -70°C for up to 12 months from date of receipt. As supplied, the enzyme is stable on ice for several hours. Activity is stable up to 6 freeze/thaw cycles (snap freezing in a dry/ice ethanol bath or liquid nitrogen).

包装信息
数量	50 µg

merck millipore,默克密理博,14-856,Ubiquitin C-terminal hydrolase L3 (UCH-L3), 50 µg

whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech