merck millipore,默克密理愽
  • merck millipore,默克密理博,420099,JAK Inhibitor I - CAS 457081-03-7 - Calbiochem

  • merck millipore,默克密理博,420099,JAK Inhibitor I - CAS 457081-03-7 - Calbiochem

    产品名称：JAK Inhibitor I - CAS 457081-03-7 - Calbiochem
    产品型号：420099
    The JAK Inhibitor I, also referenced under CAS 457081-03-7, controls the biological activity of JAK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation application More>>

    merck millipore,默克密理博,420099,JAK Inhibitor I - CAS 457081-03-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,420099,JAK Inhibitor I - CAS 457081-03-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₈H₁₆FN₃O457081-03-7
    描述
    概述 A potent, reversible, cell-permeable, and ATP-competitive inhibitor of Janus protein tyrosine kinases (JAKs). Displays potent inhibitory activity against JAK1 (IC50 = 15 nM for murine JAK1), JAK2 (IC50 = 1 nM), JAK3 (Ki = 5 nM), and Tyk2 (IC50 = 1 nM). Inhibits other kinases at much higher concentrations. Shown to inhibit IL2- and IL4-dependent proliferation of CTLL cells and block the phosphorylation of STAT5; and further induce growth inhibition of multiple myeloma cells expressing activated JAKs and STAT3, unlike AG 490 (Cat. No. 658401). A 10 mM (500 µg/162 µl) solution of JAK Inhibitor I (Cat. No. 420097) in DMSO is also available.
    产品目录编号 420099
    品牌系列 Calbiochem®
    同义词 2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, Pyridone 6, P6, DBI, JAK1 Inhibitor I, JAK2 Inhibitor I, JAK3 Inhibitor X
    参考
    参考 Pedranzini, L., et al. 2006. Cancer Res. 66, 9714.
    Lucet, I.S., et al. 2005. Blood 107, 176.
    Thompson, J.E., et al. 2002. Bioorg. Med. Chem. Lett. 12, 1219.
    产品信息
    CAS号 457081-03-7
    具有ATP竞争性 Y
    形式 Off-white solid
    Hill配方 C₁₈H₁₆FN₃O
    化学配方 C₁₈H₁₆FN₃O
    Molar Mass 309.3
    可逆 Y
    结构配方图像
    生物信息
    主靶 murine JAK1
    主靶IC50 15 nM against murine JAK1; 1 nM against JAK2; 1 nM against Tyk2
    主靶Ki 5 nM against JAK3
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,420099,JAK Inhibitor I - CAS 457081-03-7 - Calbiochem

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