merck millipore,默克密理愽
  • merck millipore,默克密理博,658400,AG 82 - CAS 118409-58-8 - Calbiochem

  • merck millipore,默克密理博,658400,AG 82 - CAS 118409-58-8 - Calbiochem

    产品名称：AG 82 - CAS 118409-58-8 - Calbiochem
    产品型号：658400
    A cell-permeable, reversible, and competitive inhibitor of substrate binding on protein tyrosine kinases.

    merck millipore,默克密理博,658400,AG 82 - CAS 118409-58-8 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,658400,AG 82 - CAS 118409-58-8 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₀H₆N₂O₃118409-58-8
    描述
    概述 A cell-permeable, reversible, and competitive inhibitor of substrate binding on protein tyrosine kinases. Inhibits epidermal growth factor receptor tyrosine kinase (IC50 = 3 µM) and the GTPase activity of transducin (IC50 = 7 µM). Inhibits neuromedin B-induced phosphorylation of p125FAK (focal adhesion kinase). Blocks the induction of inducible nitric oxide synthase in glial cells. Induces apoptosis in human leukemic cell lines.
    产品目录编号 658400
    品牌系列 Calbiochem®
    同义词 α-Cyano-(3,4,5-trihydroxy)cinnamonitrile, Tyrphostin A25
    参考
    参考 Jaleel, M., et al. 2004. Biochemistry 43, 8247.
    Tsuda, T., et al. 1997. Biochemistry 36, 16328.
    Wolbring, G., et al. 1994. J. Biol. Chem. 269, 22470.
    Bergamaschi, G., et al. 1993. Leukemia 7, 2012.
    Piontek, M., et al. 1993. Anticancer Res. 13, 2119.
    Bilder, G.E., et al. 1991. Am. J. Physiol. 260, C721.
    Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
    Yaish, P., et al. 1988. Science 242, 933.
    产品信息
    CAS号 118409-58-8
    具有ATP竞争性 Y
    形式 Dark yellow solid
    Hill配方 C₁₀H₆N₂O₃
    化学配方 C₁₀H₆N₂O₃
    Molar Mass 202.2
    可逆 Y
    结构配方图像
    生物信息
    主靶 epidermal growth factor receptor tyrosine kinase
    主靶IC50 3 µM against epidermal growth factor receptor tyrosine kinase
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or MeOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

    merck millipore,默克密理博,658400,AG 82 - CAS 118409-58-8 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,324903,Epiregulin, Human, Recombinant
下一件merck millipore产品：merck millipore,默克密理博,691400,Zebularine - CAS 654065 - Calbiochem


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