merck millipore,默克密理愽
  • merck millipore,默克密理博,04-321,Anti-4E-BP1 Antibody, rabbit monoclonal

  • merck millipore,默克密理博,04-321,Anti-4E-BP1 Antibody, rabbit monoclonal

    产品名称：Anti-4E-BP1 Antibody, rabbit monoclonal
    产品型号：04-321
    Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-4E-BP1 Antibody, Rabbit is an antibody against  More>>

    merck millipore,默克密理博,04-321,Anti-4E-BP1 Antibody, rabbit monoclonal

  • 产品介绍
  • merck millipore,默克密理博,04-321,Anti-4E-BP1 Antibody, rabbit monoclonal

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, FCRbPurifiedMonoclonal Antibody
    描述
    产品目录编号 04-321
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-4E-BP1 Antibody, rabbit monoclonal
    Alternate Names
    • EIF4EBP1, eIF4E-binding protein 1, eukaryotic translation initiation factor 4E binding protein 1
    • EIF4EBP1
    • eIF4E-binding protein 1
    产品信息
    格式 Purified
    演示 100 μL of rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 0.09 M NaCl, 0.006% sodium azide and 0.03% BSA and 40% glycerol.
    应用
    应用 Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-4E-BP1 Antibody, Rabbit is an antibody against 4E-BP1 for use in FC, WB, IH(P).
    主要应用
    • Western Blotting
    • Flow Cytometry
    生物信息
    免疫原品种 KLH-conjugated synthetic peptide corresponding to the C-terminal region of human 4E-BP1 (eIF4E-binding protein).
    宿主 Rabbit
    特异性 Recognizes the C-terminal domain of 4E-BP1.
    同种型 IgG
    品种反应性 Human
    Species Reactivity Note Not expected to react with mouse or rat.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_004095.3
    Entrez基因汇总 This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
    基因符号
    • BP-1
    • EIF4EBP1
    • PHAS-I
    • 4EBP1
    • MGC4316
    • 4E-BP1
    UniProt编号
    • Q13541
    UniProt汇总 FUNCTION: SwissProt: Q13541 # Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway.
    SIZE: 118 amino acids; 12580 Da
    SUBUNIT: Nonphosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Rapamycin can attenuate insulin stimulation, mediated by FKBPs.
    PTM: Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylated upon DNA damage, probably by ATM or ATR.
    SIMILARITY: SwissProt: Q13541 ## Belongs to the eIF4E-binding protein family.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C from date of shipment
    包装信息
    数量 100 µL

    merck millipore,默克密理博,04-321,Anti-4E-BP1 Antibody, rabbit monoclonal

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