merck millipore,默克密理愽
  • merck millipore,默克密理博,AB1665,Anti-Fas Ligand Antibody

  • merck millipore,默克密理博,AB1665,Anti-Fas Ligand Antibody

    产品名称：Anti-Fas Ligand Antibody
    产品型号：AB1665
    Detect Fas Ligand using this Anti-Fas Ligand Antibody validated for use in ELISA & WB.

    merck millipore,默克密理博,AB1665,Anti-Fas Ligand Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB1665,Anti-Fas Ligand Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, MWB, ELISARbSerumPolyclonal Antibody
    描述
    产品目录编号 AB1665
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Fas Ligand Antibody
    Alternate Names
    • FasL
    产品信息
    格式 Serum
    演示 Liquid antiserum containing 0.05% sodium merthiolate as a preservative.
    应用
    应用 Detect Fas Ligand using this Anti-Fas Ligand Antibody validated for use in ELISA & WB.
    主要应用
    • Western Blotting
    • ELISA
    应用说明 Western blotting:1:1000 - 1:5,000, using Chemiluminescent detection. The use of 0.1 - 0.5% milk in diluents is recommended to reduce background. Based upon the calculated amino acid sequences, rat (278), mouse (279), and human (281) FASL has a molecular weight of ~32 kDa. A 40 kDa FASL band has been detected in mouse T cells.

    ELISA: 1:10,000 - 1:50,000, for detection of control peptide (AG626) coated at a 1 μg/mL concentration.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 An 18 amino acid peptide sequence (aa 130-146) from rat FASL. This sequence is known to be 94% homologous with mouse FASL, differing by one amino acid. This peptide region does not show significant homology with human FASL, with only four amin
    宿主 Rabbit
    品种反应性 RatMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000639.1
    Entrez基因汇总 The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE).
    基因符号
    • APTL
    • FASLG
    • FASL
    • CD95L
    • CD178
    • TNFSF6
    • FasL
    • APT1LG1
    非反应性品种
    • Human
    UniProt编号
    • P48023
    UniProt汇总 FUNCTION: SwissProt: P48023 # Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.
    SIZE: 281 amino acids; 31485 Da
    SUBUNIT: Homotrimer (Probable).
    SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. Secreted. Note=May be released into the extracellular fluid, probably by cleavage form the cell surface.
    PTM: N-glycosylated. & The soluble form derives from the membrane form by proteolytic processing.
    DISEASE: SwissProt: P48023 # Defects in FASLG are the cause of autoimmune lymphoproliferative syndrome type 1B (ALPS1B) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
    SIMILARITY: SwissProt: P48023 ## Belongs to the tumor necrosis factor family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Store at -20°C for up to 12 months in undiluted aliquots. Avoid repeated freeze-thaw cycles.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB1665,Anti-Fas Ligand Antibody

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