merck millipore,默克密理博,679101,Vitamin D₃, 1α, 25-Dihydroxy- - CAS 32222-06-3

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merck millipore,默克密理博,679101,Vitamin D₃, 1α, 25-Dihydroxy- - CAS 32222-06-3 - Calbiochem
产品名称：Vitamin D₃, 1α, 25-Dihydroxy- - CAS 32222-06-3 - Calbiochem
产品型号：679101
Prevents the development of clinical diabetes in NOD mice, an animal model of human autoimmune diabetes.

merck millipore,默克密理博,679101,Vitamin D₃, 1α, 25-Dihydroxy- - CAS 32222-06-3 - Calbiochem

产品介绍

merck millipore,默克密理博,679101,Vitamin D₃, 1α, 25-Dihydroxy- - CAS 32222-06-3 - Calbiochem

重要规格表

经验配方	CAS号
C₂₇H₄₄O₃	32222-06-3

描述
概述	Has immunomodulatory properties in vitro and in vivo. Prevents the development of clinical diabetes in NOD mice, an animal model of human autoimmune diabetes. Regulates c-myc transcription. Induces reversible hydrolysis of sphingomyelin cycle and generates ceramide. Stimulates intestinal Ca²⁺ and phosphate transport and mobilizes Ca²⁺ from bone. Also available as a 1 mM solution in DMSO (Cat. No. 509721).
产品目录编号	679101
品牌系列	Calbiochem®
同义词	1,25-(OH)₂-D₃, Calcitriol

参考
参考	Semizarov, D., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 15412. Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125. Mathieu, C., et al. 1994. Diabetologica 37, 552. Thomasset, M. 1994. Pathol. Biol. 42, 163. Horton, W.E., Jr., et al. 1991. J. Biol. Chem. 266, 24804. Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1020. Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1189. Wakasugi, M., et al. 1991. Prostaglandins 42, 127. Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun. 166, 916. Simpson, R.U., et al. 1989. J. Biol. Chem. 264, 19710. DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem. 52, 411.

参考

Semizarov, D., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 15412.
Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
Mathieu, C., et al. 1994. Diabetologica 37, 552.
Thomasset, M. 1994. Pathol. Biol. 42, 163.
Horton, W.E., Jr., et al. 1991. J. Biol. Chem. 266, 24804.
Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1020.
Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1189.
Wakasugi, M., et al. 1991. Prostaglandins 42, 127.
Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun. 166, 916.
Simpson, R.U., et al. 1989. J. Biol. Chem. 264, 19710.
DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem. 52, 411.

产品信息
CAS号	32222-06-3
形式	Solid
Hill配方	C₂₇H₄₄O₃
化学配方	C₂₇H₄₄O₃
Molar Mass	416.7
结构配方图像

生物信息
纯度	≥99% by HPLC

理化信息
溶解度	DMSO or EtOH

GHS安全信息
RTECS	FZ4645000

安全信息
R相	R: 26/27/28-63 Very toxic by inhalation, in contact with skin and if swallowed. Possible risk of harm to the unborn child.
S相	S: 36/37/39-45 Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

储存和货运信息
货运代码	Blue Ice Only
毒性	Highly Toxic & Carcinogenic / Teratogenic
有害材料注意事项：	Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存	≤ -70°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.