merck millipore,默克密理愽
  • merck millipore,默克密理博,05-484,Anti-EGFR (non-phospho-Tyr1173) Antibody, clone 20G3

  • merck millipore,默克密理博,05-484,Anti-EGFR (non-phospho-Tyr1173) Antibody, clone 20G3

    产品名称：Anti-EGFR (non-phospho-Tyr1173) Antibody, clone 20G3
    产品型号：05-484
    Detect EGFR (non-phospho-Tyr1173) using this Anti-EGFR (non-phospho-Tyr1173) Antibody, clone 20G3 validated for use in IP & WB.

    merck millipore,默克密理博,05-484,Anti-EGFR (non-phospho-Tyr1173) Antibody, clone 20G3

  • 产品介绍
  • merck millipore,默克密理博,05-484,Anti-EGFR (non-phospho-Tyr1173) Antibody, clone 20G3

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-484
    Replaces 04-337; 04-341
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-EGFR (non-phospho-Tyr1173) Antibody, clone 20G3
    产品信息
    格式 Purified
    演示 100µg of lyophilized thiophilic and size exclusion chromatography purified mouse IgG1 from 1mL 2x PBS / 0.09 % Na-azide / PEG and Sucrose. Reconstitute with 100 µL H2O (15 min, RT) for a final concentration of 1 mg/mL.
    应用
    应用 Detect EGFR (non-phospho-Tyr1173) using this Anti-EGFR (non-phospho-Tyr1173) Antibody, clone 20G3 validated for use in IP & WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 peptide containing the unphosphorylated Tyr1173 motif (NAE[Y]LR) of the human EGF receptor
    克隆 clone 20G3
    宿主 Mouse
    特异性 The motif NAEYLR of the EGF-R (unphosphorylated at Tyr1173), this antibody does not interact with the phosphorylated (pTyr1173) form of the EGF receptor. Tyr1173 corresponds to Tyr1197 in the human (isoform a) and mouse precursor proteins, and to Tyr1196 in the mature rat and pig precursor proteins.
    同种型 IgG1κ
    品种反应性 MouseHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_005228
    基因符号
    • mENA
    • EGFR
    • ERBB1
    • ERBB
    纯化方法 Thiophilic adsoption and size exclusion chromatography
    UniProt编号
    • P00533
    UniProt汇总 FUNCTION: SwissProt: P00533 # Isoform 2/truncated isoform may act as an antagonist.
    SIZE: 1210 amino acids; 134277 Da
    SUBUNIT: Binds RIPK1. CBL interacts with the autophosphorylated C- terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1.
    SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
    TISSUE SPECIFICITY: Expressed in placenta. Isoform 2 is also expressed in ovarian cancers.
    PTM: Phosphorylation of Ser-695 is partial and occurs only if Thr- 693 is phosphorylated. & Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur.DISEASE:SwissProt: P00533 # Defects in EGFR are associated with lung cancer [MIM:211980].
    SIMILARITY: SwissProt: P00533 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.
    MISCELLANEOUS: Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on RIPA lysates from unstimulated HFF cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-484,Anti-EGFR (non-phospho-Tyr1173) Antibody, clone 20G3

上一件merck millipore产品：merck millipore,默克密理博,375670,Herbimycin A, Streptomyces sp. - CAS 70563-58-5 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,4801,Neomycin Sulfate - CAS 1405-10-3 - Calbiochem


相关产品

merck millipore,默克密理博,MABN448,Anti-ENC-1 Antibody, clone 1H8.1 merck millipore,默克密理博,MABN448,Anti-ENC-1 Antibody, clone 1H8.1

merck millipore,默克密理博,ABT28,Anti-Autotaxin Antibody merck millipore,默克密理博,ABT28,Anti-Autotaxin Antibody

merck millipore,默克密理博,AB1665,Anti-Fas Ligand Antibody merck millipore,默克密理博,AB1665,Anti-Fas Ligand Antibody

merck millipore,默克密理博,679101,Vitamin D₃, 1α, 25-Dihydroxy- - CAS 32222-06-3 - Calbiochem merck millipore,默克密理博,679101,Vitamin D₃, 1α, 25-Dihydroxy- - CAS 32222-06-3 - Calbiochem

merck millipore,默克密理博,375670,Herbimycin A, Streptomyces sp. - CAS 70563-58-5 - Calbiochem merck millipore,默克密理博,375670,Herbimycin A, Streptomyces sp. - CAS 70563-58-5 - Calbiochem

merck millipore,默克密理博,4801,Neomycin Sulfate - CAS 1405-10-3 - Calbiochem merck millipore,默克密理博,4801,Neomycin Sulfate - CAS 1405-10-3 - Calbiochem

merck millipore,默克密理博,SF-1020,FABP3; Human, Cyanine 3 RNA Detection Probe,SmartFlare merck millipore,默克密理博,SF-1020,FABP3; Human, Cyanine 3 RNA Detection Probe,SmartFlare

merck millipore,默克密理博,MAB331,Anti-SNAP-25 Antibody, clone SP14 merck millipore,默克密理博,MAB331,Anti-SNAP-25 Antibody, clone SP14

merck millipore,默克密理博,539832,Prostate Specific Antigen, Human Seminal Fluid merck millipore,默克密理博,539832,Prostate Specific Antigen, Human Seminal Fluid

merck millipore,默克密理博,07-450-S,Anti-monomethyl-Histone H3 (Lys9) Antibody, Trial Size merck millipore,默克密理博,07-450-S,Anti-monomethyl-Histone H3 (Lys9) Antibody, Trial Size


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部