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merck millipore,默克密理博,375670,Herbimycin A, Streptomyces sp. - CAS 70563-58-5 - Calbiochem
产品名称：Herbimycin A, Streptomyces sp. - CAS 70563-58-5 - Calbiochem
产品型号：375670
A potent and cell-permeable protein tyrosine kinase inhibitor.
merck millipore,默克密理博,375670,Herbimycin A, Streptomyces sp. - CAS 70563-58-5 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₃₀H₄₂N₂O₉ 70563-58-5 描述 概述 A potent and cell-permeable protein tyrosine kinase inhibitor. Inhibits p60v-src (IC50 = 12 µM) and PDGF-induced phospholipase D activation (IC50 = 8 µg/ml). Reported to inhibit c-Src related bone resorption (IC50 = 70 nM). Inhibits angiogenesis in chick chorioallantoic membrane. Also shown to inhibit anti-CD3 monoclonal antibody-induced apoptosis of thymocytes. 产品目录编号 375670 品牌系列 Calbiochem®
参考 参考 Fan, T.-P., et al. 1995. Trends Pharmacol. Sci. 16, 57.
Kim, B.Y. 1995. Biochem. Biophys. Res. Commun. 212, 1061.
Migita, K., et al. 1994. J. Immunol. 153, 3457.
Okabe, M., et al. 1994. Leuk. Res. 18, 867.
Fukazawa, H., et al. 1991. Biochem. Pharmacol. 42, 1661.
Obinata, A., et al. 1991. Exp. Cell Res. 193, 36.
Park, D.J., et al. 1991. J. Biol. Chem. 266, 24237.
Weinstein, S.L., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4148.
Oikawa, T., et al. 1989. Cancer Lett. 48, 157.
Uehara, Y., et al. 1989. Biochem. Biophys. Res. Commun. 163, 803.
Uehara, Y., et al. 1988. Virology 164, 294.
Omura, S., et al. 1979. J. Antibiotics 32, 255.产品信息 CAS号 70563-58-5 具有ATP竞争性 N 形式 Yellow solid Hill配方 C₃₀H₄₂N₂O₉ 化学配方 C₃₀H₄₂N₂O₉ Molar Mass 574.7 可逆 N 结构配方图像 生物信息 主靶 P60v-src 主靶IC50 12 µM against P60v-src 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO GHS安全信息 RTECS LX8930000 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Carcinogenic / Teratogenic
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.
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