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merck millipore,默克密理博,AB1224,Anti-Myeloperoxidase Antibody, human white cell
产品名称：Anti-Myeloperoxidase Antibody, human white cell
产品型号：AB1224
Anti-Myeloperoxidase Antibody, human white cell is an antibody against Myeloperoxidase for use in ELISA & WB.
merck millipore,默克密理博,AB1224,Anti-Myeloperoxidase Antibody, human white cell
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB, ELISA Rb Serum Polyclonal Antibody 描述 产品目录编号 AB1224 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Myeloperoxidase Antibody, human white cell Alternate Names - MPO
产品信息 格式 Serum 演示 Monospecific antiserum purified by delipidation and defibrination. Lyophilized from 0.02 M Potassium Phosphate buffer, 0.15 M Sodium Chloride, pH 7.2, 0.01% Sodium Azide. Reconstitute with 2.0 mL of sterile distilled water. 应用 应用 Anti-Myeloperoxidase Antibody, human white cell is an antibody against Myeloperoxidase for use in ELISA & WB. 主要应用 - Western Blotting
- ELISA
应用说明 Immunoblotting: antibody recognizes alpha and beta subunits of MPO. Reduced and denatured extracts of purified MPO produce blots produce 55-60kDa alpha subunits and 12-14kDa beta subunit bands140 Additional bands may be present due to cross reactivity with other myeloperoxidases.
ELISA:
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Myeloperoxidase (Human White Cells) 表位 human white cell 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Myeloperoxidase (Human White Cells). Monospecific by IEP. Some cross reactivity with Myeloperoxidase from other tissues and species may occur.
Myeloperoxidase (MPO) represents an early appearing and highly reliable intracellular myeloid lineage marker molecule. MPO protein can be detected in a subset of human hematopoietic bone marrow progenitor cells and in granulomonopoietic (GM) cells. However, other myeloid-related cell types such as epidermal Langerhans-type dendritic cells (LC) lack MPO. Therefore, human myeloid progenitors might be subdivided based on MPO protein expression into functional subsets.品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000250.1
Entrez基因汇总 Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. 基因符号 - myeloperoxidase
- MPO
UniProt编号 - P05164
UniProt汇总 FUNCTION: SwissProt: P05164 # Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
COFACTOR: Binds 1 calcium ion per heterodimer. & Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer.
SIZE: 745 amino acids; 83869 Da
SUBUNIT: Tetramer of two light chains and two heavy chains.
SUBCELLULAR LOCATION: Lysosome.
DISEASE:SwissProt: P05164 # Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.
SIMILARITY: SwissProt: P05164 ## Belongs to the peroxidase family. XPO subfamily.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Store unopened vial at 2-8 ºC. Maintain frozen at -20ºC in undiluted aliquots for up to one year after reconstitution. Avoid repeated freeze/thaw cycles. 包装信息 数量 2 mL
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