- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB16532 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Survivin Antibody, NT Alternate Names - TIAP
产品信息 格式 Purified 演示 Purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide. 应用 应用 Anti-Survivin Antibody, N-terminus detects level of Survivin & has been published & validated for use in WB. 主要应用 - Western Blotting
应用说明 Western blot: 0.5 to 1 μg/mL.
MOLT4 cell lysate can be used as positive control and an approximate 17 kDa band should be detected.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Rabbit anti-Survivin (N-terminal) polyclonal antibody was raised against a peptide corresponding to amino acids 1 to 12 of human origin (Ambrosini et al. 1997). 表位 N-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4) and TIAP1-3. Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas (Ambrosini et al. 1997). 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001168.2
- NM_001012270.1
- NM_001012271.1
Entrez基因汇总 This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of this gene's expression. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined. 基因符号 - EPR-1
- BIRC5
- IAP4
- survivin
- API4
- SVV
UniProt编号 - O15392
UniProt汇总 FUNCTION: SwissProt: O15392 # May play a role in neoplasia. May counteract a default induction of apoptosis in G2/M phase. Interacts with tubulin. Inhibitor of caspase-3 and caspase-7. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Isoforms 2 and 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti- apoptotic effects when compared with the displayed wild-type isoform.
SIZE: 142 amino acids; 16390 Da
SUBUNIT: Homodimer. When phosphorylated, interacts with HBXIP; the resulting complex binds pro-caspase-9, as well as active caspase- 9, but much less efficiently. Component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B. Interacts with EVI5.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with AURKB at mitotic chromosomes.
TISSUE SPECIFICITY: Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines.
DOMAIN: SwissProt: O15392 The BIR repeat is necessary and sufficient for HBXIP binding.
SIMILARITY: Belongs to the IAP family. & Contains 1 BIR repeat.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 12 months. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,70006,T7SelectDOWN Primer
下一件merck millipore产品：merck millipore,默克密理博,09-448,Anti-phospho-IRS1 (Ser612) mouse/ (Ser616) human Antibody
相关产品
merck millipore,默克密理博,07-1218,Anti-PP1γ1 Antibody
merck millipore,默克密理博,CBL56,Anti-Adrenocorticotropic Hormone Antibody, CT, clone 56
merck millipore,默克密理博,216275,5-Carboxyfluorescein Diacetate - CAS 79955-27-4 - Calbiochem
merck millipore,默克密理博,14-745,TAO3 Protein, active, 10 µg
merck millipore,默克密理博,70006,T7SelectDOWN Primer
merck millipore,默克密理博,09-448,Anti-phospho-IRS1 (Ser612) mouse/ (Ser616) human Antibody
merck millipore,默克密理博,AB2267,Anti-LCN2 Antibody
merck millipore,默克密理博,MABN674,Anti-PSIP1 Antibody, clone 6E4
merck millipore,默克密理博,AB5889,Anti-Capsaicin Receptor Antibody, NT
