merck millipore,默克密理愽
  • merck millipore,默克密理博,CBL56,Anti-Adrenocorticotropic Hormone Antibody, CT, clone 56

  • merck millipore,默克密理博,CBL56,Anti-Adrenocorticotropic Hormone Antibody, CT, clone 56

    产品名称：Anti-Adrenocorticotropic Hormone Antibody, CT, clone 56
    产品型号：CBL56
    Anti-Adrenocorticotropic Hormone Antibody, C-terminus, clone 56 is an antibody against Adrenocorticotropic Hormone for use in ELISA, IH(P).

    merck millipore,默克密理博,CBL56,Anti-Adrenocorticotropic Hormone Antibody, CT, clone 56

  • 产品介绍
  • merck millipore,默克密理博,CBL56,Anti-Adrenocorticotropic Hormone Antibody, CT, clone 56

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, HELISAMPurifiedMonoclonal Antibody
    描述
    产品目录编号 CBL56
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Adrenocorticotropic Hormone Antibody, CT, clone 56
    Alternate Names
    • ACTH
    产品信息
    格式 Purified
    演示 The monoclonal is presented as 1mg in 1ml phosphate buffered saline containing 0.1% sodium azide. We recommend that each laboratory determine an optimum working titre for use in its particular application.
    应用
    应用 Anti-Adrenocorticotropic Hormone Antibody, C-terminus, clone 56 is an antibody against Adrenocorticotropic Hormone for use in ELISA, IH(P).
    主要应用
    • ELISA
    应用说明 This antibody reacts with solid phase ACTH either captured as part of a sandwich or adsorbed as a solid phase antigen and as such is suitable for serum assay development

    The antibody is also reactive on formalin fixed paraffin wax embedded tissue and is therefore suitable for immunocytochemistry

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 ACTH-BSA Conjugate
    表位 C-terminus
    克隆 56
    宿主 Mouse
    特异性 This antibody is specific for CLIP (17-39 ACTH) and no cross reaction with Synacthen (1-24 ACTH).

    KNOWN SPECIES CROSS REACTIVITY: Positive with rat C-terminal ACTH
    同种型 IgG1
    品种反应性 RatHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_001035256.1
    • NM_000939.2
    Entrez基因汇总 This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
    基因符号
    • gamma-MSH
    • POMC
    • pro-ACTH-endorphin
    • adrenocorticotropin
    • beta-LPH
    • POC
    • gamma-LPH
    • LPH
    • ACTH
    • corticotropin
    • beta-endorphin
    • beta-MSH
    • alpha-MSH
    • pro-opiomelanocortin
    • proopiomelanocortin
    • Pro-opiomelanocortin
    • corticotropin-lipotrophin
    • NPP
    • MSH
    • met-enkephalin
    • CLIP
    UniProt编号
    • P01189
    UniProt汇总 FUNCTION: SwissProt: P01189 # Beta-endorphin and Met-enkephalin are endogenous opiates.
    SIZE: 267 amino acids; 29424 Da
    TISSUE SPECIFICITY: ACTH and MSH are produced by the pituitary gland.
    PTM: Specific enzymatic cleavages at paired basic residues yield the different active peptides. & O-glycosylated; reducing sugar is probably N- acetylgalactosamine.
    DISEASE: SwissProt: P01189 # Defects in POMC may be associated with susceptibility to obesity [MIM:601665]. & Defects in POMC are the cause of pro-opiomelanocortinin deficiency [MIM:609734]. Affected individuals present early-onset obesity, adrenal insufficiency and red hair.
    SIMILARITY: SwissProt: P01189 ## Belongs to the POMC family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
    包装信息
    数量 1 mg

    merck millipore,默克密理博,CBL56,Anti-Adrenocorticotropic Hormone Antibody, CT, clone 56

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