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Replacement Information Replacement Information 07-1218 is a recommended replacement for AB4084 重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, B, H, M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-1218 Replaces AB4084 品牌系列 Upstate
商名 - Upstate
描述 Anti-PP1γ1 Antibody Alternate Names - Serine/threonine phosphatase 1 gamma
- Protein phosphatase 1C catalytic subunit
- Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
- Protein phosphatase 1, catalytic subunit, gamma isoform
- catalytic subunit
- gamma isoform
背景信息 Type 1 protein Ser/Thr phosphatases (PP1) have a high specific activity against phosphorylase, and are resistant to okadaic acid up to concentrations of 50 nM, but sensitive to Inhibitor-2 and microcystin LR. 产品信息 格式 Purified 控制 - HeLa Cell Lysate
演示 Purified rabbit polyclonal IgG provided as 0.2µm sterile filtered solution in phosphate buffered saline with 0.08% sodium azide. 应用 应用 Anti-PP1γ1 Antibody detects level of PP1γ1 & has been published & validated for use in WB & IP. 主要应用 - Western Blotting
应用说明 Immunoprecipitation: A previous lot of this antibody was used on Immunoprecipitation. 生物信息 免疫原品种 The immunogen used to the purified peptide conjugated to KLH corresponding to the to the C –terminus of PP1 gamma 1 catalytic subunit (amino acids 311-323). 表位 C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes Protein Phosphatase 1γ1. No cross reactivity with other recombinant PP1 isoforms. 同种型 IgG 品种反应性 RatBovineHumanMouse Species Reactivity Note Bovine,Human, Mouse, Rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002710.1
基因符号 - EC 3.1.3.16
- PPP1CC
- PP-1G
- PPP1G
纯化方法 Purified UniProt编号 - P36873
UniProt汇总 FUNCTION: SwissProt: P36873 # Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II.
COFACTOR: Binds 1 iron ion per subunit. & Binds 1 manganese ion per subunit.
SIZE: 323 amino acids; 36984 Da
SUBUNIT: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A and PPP1R12B mediate binding to myosin. PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen. Interacts with cyanobacterial toxin microcystin; disulfide-linked. Interacts with PPP1R7. Isoform gamma-2 interacts with SPZ1 (By similarity). Interacts with CDCA2.
SUBCELLULAR LOCATION: Cytoplasm. Note=Colocalizes with SPZ1 in the nucleus (By similarity).
SIMILARITY: SwissProt: P36873 ## Belongs to the PPP phosphatase family. PP-1 subfamily.
MISCELLANEOUS: Microcystin toxin is bound to Cys-273 through a thioether bond.产品使用声明 质量保证 Routinely evaluated by Western Blot on HeLa lysates.
Western Blot Analysis: 1:500 dilution of this lot detected PP-1 GAMMA on 10 μg of HeLa lysates.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 1 year from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µg
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