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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M, B IHC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB2267 描述 Anti-LCN2 Antibody Alternate Names - Lipocalin-2
- lipocalin 2
- migration-stimulating factor inhibitor
- siderocalin
- Oncogene 24p3
- 25 kDa alpha-2-microglobulin-related subunit of MMP-9
- lipocalin 2 (oncogene 24p3)
- neutrophil gelatinase-associated lipocalin
背景信息 LCN2 (also known as Neurophil Gelatinase-Associated Lipocalin or NGAL) belongs to a superfamily of lipocalins, a collection of small, diversely functional, extracellular proteins. NGAL is secreted from neutrophil granules in three different forms; a monomer of 25 kDa, a disulfide-linked homodimer at 46 kDa, and a disulfide-linked heterodimer with MMP-9 at 135-kDa. It is widely known to induce development of kidney epithelia, to bind and traffic iron, and to act as a molecular signal under inflammatory conditions, such as Crohn’s Disease. Multiple carcinoma studies have also shown elevated expression levels of LCN2 in several different human tumors affecting such organs as: colon, lung, breast, ovaries and pancreas. Additionally, there has been great interest in this protein as a possible marker for: onset of Acute Kidney Injury following cardiac surgery, the progression of Chronic Kidney Disease (CKD), and the survival chances of patients with Chronic Heart Failure (CHF). 产品信息 格式 Affinity Purified 控制 - Human kidney tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 Anti-LCN2 Antibody detects level of LCN2 & has been published & validated for use in WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:200 dilution of Anti-LCN2 antibody from a previous lot detected LCN2 in human spleen tissue. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the mature chain of human LCN2. 表位 Mature chain 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes LCN2. 品种反应性 RatHumanMouseBovine Species Reactivity Note Demonstrated to react with human. Predicted to react with mouse, bovine, and rat based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_005555
基因符号 - LCN2
- NGAL
- 24p3
- p25
- MSFI
- HNL
纯化方法 Affinity Purfied UniProt编号 - P80188
UniProt汇总 FUNCTION: Transport of small lipophilic substances Potential.
SUBUNIT STRUCTURE: Forms a covalently linked, disulfide-bridged heterodimer with the 92 kDa type V collagenase (MMP-9).
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lungs. Not found in the small intestine or peripheral blood leukocytes.
SEQUENCE SIMILARITIES: Belongs to the calycin superfamily. Lipocalin family.产品使用声明 质量保证 Evaluated by Western Blot in human kidney tissue lysate.
Western Blot Analysis: 5 µg/mL of this antibody detected LCN2 in 10 µg of human kidney tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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