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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB15580 Replaces AB5686 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-NeuroD 1 Antibody Alternate Names - Neurogenic differentiation factor 1
产品信息 格式 Affinity Purified 演示 Liquid in PBS with 0.1% sodium azide. 应用 应用 Detect NeuroD 1 using this Anti-NeuroD 1 Antibody validated for use in WB. 主要应用 - Western Blotting
应用说明 Western blot: 0.5-1.0 μg/mL on mouse brain lysate.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide 宿主 Rabbit 特异性 NeuroD1 (Neurogenic differentiation factor 1). By Western blot the antibody recognizes a band at ~45 kDa on human, rat and mouse brain lysate. 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002500.2
Entrez基因汇总 This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus. 基因符号 - NIDDM
- NEUROD1
- NeuroD1
- NeuroD
- BETA2
- BHF-1
- NEUROD
纯化方法 Immunoaffinity purified UniProt编号 - Q13562
UniProt汇总 FUNCTION: SwissProt: Q13562 # Differentiation factor required for dendrite morphogenesis and maintenance in the cerebellar cortex. Transcriptional activator. Binds to the insulin gene E-box.
SIZE: 356 amino acids; 39890 Da
SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer with TCF3/E47. Interacts with RREB1.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity).
PTM: Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-335; which promotes dendritic growth (By similarity).
DISEASE: SwissProt: Q13562 # Defects in NEUROD1 are the cause of maturity onset diabetes of the young type 6 (MODY6) [MIM:606394]. MODY [MIM:606391] is characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.
SIMILARITY: SwissProt: Q13562 ## Contains 1 basic helix-loop-helix (bHLH) domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. 包装信息 数量 100 µg
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