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merck millipore,默克密理博,528119,PI 3-K Inhibitor XI, HWT - CAS 58053-83-1 - Calbiochem
产品名称：PI 3-K Inhibitor XI, HWT - CAS 58053-83-1 - Calbiochem
产品型号：528119
The PI 3-K Inhibitor XI, HWT, also referenced under CAS 58053-83-1, controls the biological activity of PI 3-K. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation More>>
merck millipore,默克密理博,528119,PI 3-K Inhibitor XI, HWT - CAS 58053-83-1 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₃H₂₆O₈ 58053-83-1 描述 概述 A cell-permeable Wortmannin (Cat. Nos. 681675 and 681676) 17β-Hydroxy analog (HWT) that acts as an irreversible PI 3-K inhibitor with an 8.4-fold higher potency than that of Wortmannin (IC50 = 0.5 and 4.2 nM, respectively) and inhibits mTOR only at much higher concentrations (IC50 = 0.193 µM). Both Wortmannin and HWT covalently modify a conserved lysine residue (Lys833 in porcine PI 3-Kγ) in the PI 3-K ATP binding pocket via their electrophilic furan ring at C-20 position. HWT is shown to effectively arrest the growth of LNCaP cells (IC50 = 1.464 µM) in vitro, however, its high in vivo toxicity renders it unsuitable for tumor killing studies in mice. Also reported to inhibit late phase PLD-mediated PA production upon fMLP (Cat. No. 05-22-2500) stimulation of human neutrophils. 产品目录编号 528119 品牌系列 Calbiochem®
同义词 Wortmannin, 17β-Hydroxy, LY 301497, mTOR Inhibitor VIII 参考 参考 Zask, A., et al. 2008. J. Med. Chem. 51, 1319.
Zhu, T., et al. 2006. J. Med. Chem. 49, 1373.
Norman, B. H., et al. 1996. J. Med. Chem. 39, 1106.
Gelas, P., et al. 1992. Biochem. J. 287, 67.产品信息 CAS号 58053-83-1 形式 Off-white solid Hill配方 C₂₃H₂₆O₈ 化学配方 C₂₃H₂₆O₈ Molar Mass 430.5 结构配方图像 生物信息 纯度 ≥97% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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