- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,126871,Alsterpaullone, 2-Cyanoethyl - CAS 852529-97-0 - Calbiochem
产品名称：Alsterpaullone, 2-Cyanoethyl - CAS 852529-97-0 - Calbiochem
产品型号：126871
A cell-permeable and reversible Alsterpaullone derivative that acts as a highly potent, ATP-competitive, selective inhibitor of Cdk1/cyclin B and GSK-3β.
merck millipore,默克密理博,126871,Alsterpaullone, 2-Cyanoethyl - CAS 852529-97-0 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₉H₁₄N₄O₃ 852529-97-0 描述 概述 A cell-permeable and reversible Alsterpaullone (Cat. No. 126870) derivative that acts as a highly potent, ATP-competitive, selective inhibitor of Cdk1/cyclin B and GSK-3β (IC50 = 230 pM and 800 pM, respectively; [ATP] = 15 µM). Displays ~37-fold greater selectivity for Cdk1/cyclin B over Cdk5/p25 (IC50 = 30 nM). Shown to inhibit other kinases in a commercially available testing screen panel (pIC50 = −logIC50[M]; pIC50 = ~ 7.5, 7.0, 7.0, 6.5, 6.5, 6.0, and 6.0 for Cdk2/A, Cdk4/D1, GSK-3β, PDGFRβ, Src, VEGFR-2, and VEGFR-3, respectively; [ATP] = 1 µM). 产品目录编号 126871 品牌系列 Calbiochem®
同义词 3-(6-Oxo-9-nitro-5,6,7,12-tetrahydroindolo[3,2-d][1]benzazepin-2-yl)propionitrile 参考 参考 Kunick, C., et al. 2005. ChemBioChem. 6, 541. 产品信息 CAS号 852529-97-0 具有ATP竞争性 Y 形式 Light orange solid Hill配方 C₁₉H₁₄N₄O₃ 化学配方 C₁₉H₁₄N₄O₃ Molar Mass 346.3 可逆 Y 结构配方图像 生物信息 主靶 Cdkl/Gsk-3β, Cyclin B 主靶IC50 230 pM and 800 pM, [ATP] = 15 µM, against Cdk1/cyclin B and GSK-3β, respectively 纯度 ≥90% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and refrigerate (4°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,SF-3214,TBC1D4; Human, Cyanine 5 RNA Detection Probe,SmartFlare
下一件merck millipore产品：merck millipore,默克密理博,MAB1976Z-K,Anti-Integrin αVβ3, Clone LM609, Azide Free
merck millipore,默克密理博,AB9780-200UL,Anti-TWIK-1 Antibody
merck millipore,默克密理博,MABN293,Anti-Peripherin-2 Antibody, clone 6B10.1
merck millipore,默克密理博,MABT29,Anti-Ninein Antibody, clone 79-160-7
merck millipore,默克密理博,MSIPN4W50,MultiScreenHTS IP，0.45 µm，白色，非无菌
merck millipore,默克密理博,SF-3214,TBC1D4; Human, Cyanine 5 RNA Detection Probe,SmartFlare
merck millipore,默克密理博,MAB1976Z-K,Anti-Integrin αVβ3, Clone LM609, Azide Free
merck millipore,默克密理博,ES-009-C,EmbryoMax ES Cell Qualified Fetal Bovine Serum
merck millipore,默克密理博,203881,CR8, (R)-Isomer - CAS 294646-77-8 - Calbiochem
merck millipore,默克密理博,528119,PI 3-K Inhibitor XI, HWT - CAS 58053-83-1 - Calbiochem
merck millipore,默克密理博,218716,Casein Kinase I Inhibitor II, PF-670462 - CAS 950912-80-8 - Calbiochem